Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts
Background: Warts are a frequent skin condition. Human papillomavirus is the culprit (HPV). One of the warts treatments is intralesional immunotherapy utilizing the Candida antigen. Objectives: To evaluate the efficacy of candida antigen in treatment of patients with plane warts. Patients and meth...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2023-07-01
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| Series: | SVU - International Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://svuijm.journals.ekb.eg/article_291838.html |
| _version_ | 1797837235414892544 |
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| author | Hassan Mohammed Ibrahim Randa Abd Al-Naser Hussien Kamel* Mohammed Abu El-Hamd Eisa Mohamed Hegazy |
| author_facet | Hassan Mohammed Ibrahim Randa Abd Al-Naser Hussien Kamel* Mohammed Abu El-Hamd Eisa Mohamed Hegazy |
| author_sort | Hassan Mohammed Ibrahim |
| collection | DOAJ |
| description | Background: Warts are a frequent skin condition. Human papillomavirus is the culprit (HPV). One of the warts treatments is intralesional immunotherapy utilizing the Candida antigen.
Objectives: To evaluate the efficacy of candida antigen in treatment of patients with plane warts.
Patients and methods: Sixty Egyptian patients were randomly assigned into two groups for this study, each with clinically obvious plane warts: Thirty patients were divided into two groups: group (A) received injections of Candida antigen, and group (B) received intralesional saline. Before each injection, one month later, and six months following the final injection, all patients were clinically and visually assessed.
Results: The mean age of the studied group was 21.8 ± 6.6 years with 53.7% males and 46.3% females, for the cases group, and the mean age was 24 ± 7.5 years with 46.3% males for the control group. We showed statistical significant difference (p-value < 0.001) between studied groups as regard response at 1 month, 2 month and 6 month. We found Statistically significant (p < 0.001) increased percentage of complete resolution in group I (11 patients, 36.7%) when compared with group II (0 patients, 0%). There was statistical significant (p2 < 0.001) increased percentage of partial resolution (12 patients, 40%) in group I when compared with group II. During the current study, no serious adverse events were observed, and no patients discontinued treatment as a result of side effects. Erythema (26.7%) and edoema (23.3% of all adverse events) were the most common.
Conclusion: Intralesional Candida antigen immunotherapy is safe, promising and efficient treatment approach for warts. |
| first_indexed | 2024-04-09T15:21:46Z |
| format | Article |
| id | doaj.art-74077c1bf04547f69416b486e7b57ebb |
| institution | Directory Open Access Journal |
| issn | 2735-427X 2636-3402 |
| language | English |
| last_indexed | 2024-04-09T15:21:46Z |
| publishDate | 2023-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-74077c1bf04547f69416b486e7b57ebb2023-04-29T08:10:05ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022023-07-01624955https://dx.doi.org/10.21608/svuijm.2023.187360.1495 Immunotherapy with Intralesional Candida Albicans Antigen in Plane WartsHassan Mohammed Ibrahim0 Randa Abd Al-Naser Hussien Kamel*1 Mohammed Abu El-Hamd2Eisa Mohamed Hegazy3Dermatology, Venereology, and Andrology Department, Faculty of Medicine, South Valley University, Qena, Egypt.Dermatology, Venereology, and Andrology Department, Faculty of Medicine, South Valley University, Qena, Egypt.Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Sohag University, Sohag, EgyptDermatology, Venereology, and Andrology Department, Faculty of Medicine, South Valley University, Qena, Egypt.Background: Warts are a frequent skin condition. Human papillomavirus is the culprit (HPV). One of the warts treatments is intralesional immunotherapy utilizing the Candida antigen. Objectives: To evaluate the efficacy of candida antigen in treatment of patients with plane warts. Patients and methods: Sixty Egyptian patients were randomly assigned into two groups for this study, each with clinically obvious plane warts: Thirty patients were divided into two groups: group (A) received injections of Candida antigen, and group (B) received intralesional saline. Before each injection, one month later, and six months following the final injection, all patients were clinically and visually assessed. Results: The mean age of the studied group was 21.8 ± 6.6 years with 53.7% males and 46.3% females, for the cases group, and the mean age was 24 ± 7.5 years with 46.3% males for the control group. We showed statistical significant difference (p-value < 0.001) between studied groups as regard response at 1 month, 2 month and 6 month. We found Statistically significant (p < 0.001) increased percentage of complete resolution in group I (11 patients, 36.7%) when compared with group II (0 patients, 0%). There was statistical significant (p2 < 0.001) increased percentage of partial resolution (12 patients, 40%) in group I when compared with group II. During the current study, no serious adverse events were observed, and no patients discontinued treatment as a result of side effects. Erythema (26.7%) and edoema (23.3% of all adverse events) were the most common. Conclusion: Intralesional Candida antigen immunotherapy is safe, promising and efficient treatment approach for warts.https://svuijm.journals.ekb.eg/article_291838.htmlwarts; candida; intralesional |
| spellingShingle | Hassan Mohammed Ibrahim Randa Abd Al-Naser Hussien Kamel* Mohammed Abu El-Hamd Eisa Mohamed Hegazy Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts SVU - International Journal of Medical Sciences warts; candida; intralesional |
| title | Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts |
| title_full | Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts |
| title_fullStr | Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts |
| title_full_unstemmed | Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts |
| title_short | Immunotherapy with Intralesional Candida Albicans Antigen in Plane Warts |
| title_sort | immunotherapy with intralesional candida albicans antigen in plane warts |
| topic | warts; candida; intralesional |
| url | https://svuijm.journals.ekb.eg/article_291838.html |
| work_keys_str_mv | AT hassanmohammedibrahim immunotherapywithintralesionalcandidaalbicansantigeninplanewarts AT randaabdalnaserhussienkamel immunotherapywithintralesionalcandidaalbicansantigeninplanewarts AT mohammedabuelhamd immunotherapywithintralesionalcandidaalbicansantigeninplanewarts AT eisamohamedhegazy immunotherapywithintralesionalcandidaalbicansantigeninplanewarts |