Effects of a Fully Humanized Type II Anti-CD20 Monoclonal Antibody on Peripheral and CNS B Cells in a Transgenic Mouse Model of Multiple Sclerosis

Effects of a Fully Humanized Type II Anti-CD20 Monoclonal Antibody on Peripheral and CNS B Cells in a Transgenic Mouse Model of Multiple Sclerosis

Successful therapy with anti-CD20 monoclonal antibodies (mAbs) has reinforced the key role of B cells in the immunopathology of multiple sclerosis (MS). This study aimed to determine the effects of a novel class of anti-CD20 mAbs on vascular and extravascular central nervous system (CNS)-infiltratin...

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Bibliographic Details
Main Authors: Sabine Tacke, Rittika Chunder, Verena Schropp, Eduard Urich, Stefanie Kuerten
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
B cells
CD20
experimental autoimmune encephalomyelitis
multiple sclerosis
obinutuzumab
rituximab
Online Access:https://www.mdpi.com/1422-0067/23/6/3172

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