Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication
Background and Aim: Citrobacter is a gram-negative, nonsporeforming, facultative anaerobic and motile bacillus within the family of Enterobacteriaceae and is ubiquitous in nature. This opportunistic pathogen causes a wide spectrum of infections. The aim of the present study was to examine the isolat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Birjand University of Medical Sciences and Health Services
2014-11-01
|
| Series: | مجله دانشگاه علوم پزشکی بیرجند |
| Subjects: | |
| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-1403-1&slc_lang=en&sid=1 |
| _version_ | 1818466323404947456 |
|---|---|
| author | Seyedeh Somayeh Jasemi Farzad Alipoor Sanaz Dehbashi Jalal Mardaneh |
| author_facet | Seyedeh Somayeh Jasemi Farzad Alipoor Sanaz Dehbashi Jalal Mardaneh |
| author_sort | Seyedeh Somayeh Jasemi |
| collection | DOAJ |
| description | Background and Aim: Citrobacter is a gram-negative, nonsporeforming, facultative anaerobic and motile bacillus within the family of Enterobacteriaceae and is ubiquitous in nature. This opportunistic pathogen causes a wide spectrum of infections. The aim of the present study was to examine the isolation of Citrobacter spp. from blood specimens in patients hospitalized in Kermanshah Imam Khomeini hospital and to determine the isolates sensitivity to antibiotics.
Materials and Methods: This cross- sectional study was carried out on 2285 blood specimens collected from hospitalized patients between March 2012 and February 2012. In the beginning, the blood samples were inoculated in blood culture tubes media. The Citrobacter spp. isolates were identified and their identification was confirmed by means of morphological and biochemical laboratory tests. Drug sensitivity test was carried out according to CLSI (2011) recommendations through using the standard disc diffusion method.
Results: In this study Citrobacter spp. were isolated from 21 (15.8%) of 133 culture positive blood specimens collected from the hospitalized patients. The most effective antimicrobial agents against Citrobacter isolates were imipenem (90.4%), and amikacin (71.5%), respectively. The most frequent resistance observed was to cephalothin (76.2%), ciprofloxacin (76.2%), ceftazidime (66.6%) and co-trimoxazole (62%).
Conclusion: Citrobacter isolates showed high resistance to betalactam antibiotics. Therefore, it is necessary that these drugs should only be administered to patients whose diagnostic isolates reveal sensitivity in vitro. |
| first_indexed | 2024-04-13T20:57:05Z |
| format | Article |
| id | doaj.art-7409835fec1849fbbeb80ba6e18ef3f4 |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-04-13T20:57:05Z |
| publishDate | 2014-11-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-7409835fec1849fbbeb80ba6e18ef3f42022-12-22T02:30:16ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522014-11-01213394400Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short CommunicationSeyedeh Somayeh Jasemi0Farzad Alipoor1Sanaz Dehbashi2Jalal Mardaneh3 Department of pathobiology, Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Medical Microbiology Laboratory, Emam Khomeni Hospital, Kermanshah, Iran گروه پاتوبیولوژی، بخش میکروبشناسی، دانشکده بهداشت، دانشگاه علوم پزشکی تهران، تهران، ایران in Medical Bacteriology, Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Background and Aim: Citrobacter is a gram-negative, nonsporeforming, facultative anaerobic and motile bacillus within the family of Enterobacteriaceae and is ubiquitous in nature. This opportunistic pathogen causes a wide spectrum of infections. The aim of the present study was to examine the isolation of Citrobacter spp. from blood specimens in patients hospitalized in Kermanshah Imam Khomeini hospital and to determine the isolates sensitivity to antibiotics. Materials and Methods: This cross- sectional study was carried out on 2285 blood specimens collected from hospitalized patients between March 2012 and February 2012. In the beginning, the blood samples were inoculated in blood culture tubes media. The Citrobacter spp. isolates were identified and their identification was confirmed by means of morphological and biochemical laboratory tests. Drug sensitivity test was carried out according to CLSI (2011) recommendations through using the standard disc diffusion method. Results: In this study Citrobacter spp. were isolated from 21 (15.8%) of 133 culture positive blood specimens collected from the hospitalized patients. The most effective antimicrobial agents against Citrobacter isolates were imipenem (90.4%), and amikacin (71.5%), respectively. The most frequent resistance observed was to cephalothin (76.2%), ciprofloxacin (76.2%), ceftazidime (66.6%) and co-trimoxazole (62%). Conclusion: Citrobacter isolates showed high resistance to betalactam antibiotics. Therefore, it is necessary that these drugs should only be administered to patients whose diagnostic isolates reveal sensitivity in vitro.http://journal.bums.ac.ir/browse.php?a_code=A-10-1403-1&slc_lang=en&sid=1Hospitalized patients Blood infections Citrobacter spp Antibiotic resistance |
| spellingShingle | Seyedeh Somayeh Jasemi Farzad Alipoor Sanaz Dehbashi Jalal Mardaneh Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication مجله دانشگاه علوم پزشکی بیرجند Hospitalized patients Blood infections Citrobacter spp Antibiotic resistance |
| title | Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication |
| title_full | Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication |
| title_fullStr | Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication |
| title_full_unstemmed | Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication |
| title_short | Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication |
| title_sort | isolation of citrobacter spp from blood specimens in patients hospitalized in kermanshah imam khomeini hospital and determination of the of isolates sensitivity to antibiotics short communication |
| topic | Hospitalized patients Blood infections Citrobacter spp Antibiotic resistance |
| url | http://journal.bums.ac.ir/browse.php?a_code=A-10-1403-1&slc_lang=en&sid=1 |
| work_keys_str_mv | AT seyedehsomayehjasemi isolationofcitrobactersppfrombloodspecimensinpatientshospitalizedinkermanshahimamkhomeinihospitalanddeterminationoftheofisolatessensitivitytoantibioticsshortcommunication AT farzadalipoor isolationofcitrobactersppfrombloodspecimensinpatientshospitalizedinkermanshahimamkhomeinihospitalanddeterminationoftheofisolatessensitivitytoantibioticsshortcommunication AT sanazdehbashi isolationofcitrobactersppfrombloodspecimensinpatientshospitalizedinkermanshahimamkhomeinihospitalanddeterminationoftheofisolatessensitivitytoantibioticsshortcommunication AT jalalmardaneh isolationofcitrobactersppfrombloodspecimensinpatientshospitalizedinkermanshahimamkhomeinihospitalanddeterminationoftheofisolatessensitivitytoantibioticsshortcommunication |