Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress...
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| Format: | Article |
| Language: | English |
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The Korean Academy of Tuberculosis and Respiratory Diseases
2022-07-01
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| Series: | Tuberculosis and Respiratory Diseases |
| Subjects: | |
| Online Access: | http://e-trd.org/upload/pdf/trd-2021-0162.pdf |
| _version_ | 1828335570786451456 |
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| author | Woo Ho Ban Chin Kook Rhee |
| author_facet | Woo Ho Ban Chin Kook Rhee |
| author_sort | Woo Ho Ban |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker. |
| first_indexed | 2024-04-13T21:48:02Z |
| format | Article |
| id | doaj.art-740b4ac83e69455c812080f83d1a8c27 |
| institution | Directory Open Access Journal |
| issn | 1738-3536 2005-6184 |
| language | English |
| last_indexed | 2024-04-13T21:48:02Z |
| publishDate | 2022-07-01 |
| publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
| record_format | Article |
| series | Tuberculosis and Respiratory Diseases |
| spelling | doaj.art-740b4ac83e69455c812080f83d1a8c272022-12-22T02:28:29ZengThe Korean Academy of Tuberculosis and Respiratory DiseasesTuberculosis and Respiratory Diseases1738-35362005-61842022-07-0185322122610.4046/trd.2021.01624615Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary DiseaseWoo Ho Ban0Chin Kook Rhee1 Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaChronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker.http://e-trd.org/upload/pdf/trd-2021-0162.pdfchronic obstructive pulmonary diseasenuclear factor erythroid 2‒related factor 2oxidative stressinflammationbiomarker |
| spellingShingle | Woo Ho Ban Chin Kook Rhee Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease Tuberculosis and Respiratory Diseases chronic obstructive pulmonary disease nuclear factor erythroid 2‒related factor 2 oxidative stress inflammation biomarker |
| title | Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease |
| title_full | Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease |
| title_short | Role of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease |
| title_sort | role of nuclear factor erythroid 2 related factor 2 in chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease nuclear factor erythroid 2‒related factor 2 oxidative stress inflammation biomarker |
| url | http://e-trd.org/upload/pdf/trd-2021-0162.pdf |
| work_keys_str_mv | AT woohoban roleofnuclearfactorerythroid2relatedfactor2inchronicobstructivepulmonarydisease AT chinkookrhee roleofnuclearfactorerythroid2relatedfactor2inchronicobstructivepulmonarydisease |