The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases
Inflammatory rheumatic diseases (IRDs) are complex immune-mediated diseases that are characterized by chronic inflammation of the joints. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Both RA and a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/536 |
| _version_ | 1797622132345143296 |
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| author | Eric Toussirot |
| author_facet | Eric Toussirot |
| author_sort | Eric Toussirot |
| collection | DOAJ |
| description | Inflammatory rheumatic diseases (IRDs) are complex immune-mediated diseases that are characterized by chronic inflammation of the joints. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Both RA and ax SpA are characterized by a chronic course with progressive structural modifications, namely, cartilage damage and bone erosions in RA and osteoproliferative changes with spinal ossifications in ax SpA. The adipose tissue is involved in the pathophysiology of IRDs via the release of several proteins, namely, adipokines. Several adipokines with pro-inflammatory effects have been identified, such as leptin, adiponectin, visfatin and resistin. In this review, we discuss the role that adipokines may play in the structural modifications of the peripheral joints and/or axial skeleton. In RA, the role of leptin in structural damage remains controversial, while adiponectin and its high-molecular-weight isoform are known to have an influence on the development of bone erosions and radiographic progression. Resistin also appears to be a potent detrimental adipokine for the joints in RA. In ax SpA, visfatin seems to be an attractive candidate for radiographic progression, while leptin and adiponectin have negative effects on radiographic progression. |
| first_indexed | 2024-03-11T09:06:59Z |
| format | Article |
| id | doaj.art-740d6ad28b11497fb128ec75e3acd4e7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:06:59Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-740d6ad28b11497fb128ec75e3acd4e72023-11-16T19:19:40ZengMDPI AGBiomedicines2227-90592023-02-0111253610.3390/biomedicines11020536The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic DiseasesEric Toussirot0INSERM CIC-1431, Centre d’Investigation Clinique Biothérapie, Pôle Recherche, CHU de Besançon, 25000 Besançon, FranceInflammatory rheumatic diseases (IRDs) are complex immune-mediated diseases that are characterized by chronic inflammation of the joints. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Both RA and ax SpA are characterized by a chronic course with progressive structural modifications, namely, cartilage damage and bone erosions in RA and osteoproliferative changes with spinal ossifications in ax SpA. The adipose tissue is involved in the pathophysiology of IRDs via the release of several proteins, namely, adipokines. Several adipokines with pro-inflammatory effects have been identified, such as leptin, adiponectin, visfatin and resistin. In this review, we discuss the role that adipokines may play in the structural modifications of the peripheral joints and/or axial skeleton. In RA, the role of leptin in structural damage remains controversial, while adiponectin and its high-molecular-weight isoform are known to have an influence on the development of bone erosions and radiographic progression. Resistin also appears to be a potent detrimental adipokine for the joints in RA. In ax SpA, visfatin seems to be an attractive candidate for radiographic progression, while leptin and adiponectin have negative effects on radiographic progression.https://www.mdpi.com/2227-9059/11/2/536adipokinesrheumatoid arthritisaxial spondyloarthritisbone erosionsyndesmophyte |
| spellingShingle | Eric Toussirot The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases Biomedicines adipokines rheumatoid arthritis axial spondyloarthritis bone erosion syndesmophyte |
| title | The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases |
| title_full | The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases |
| title_fullStr | The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases |
| title_full_unstemmed | The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases |
| title_short | The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases |
| title_sort | influence of adipokines on radiographic damage in inflammatory rheumatic diseases |
| topic | adipokines rheumatoid arthritis axial spondyloarthritis bone erosion syndesmophyte |
| url | https://www.mdpi.com/2227-9059/11/2/536 |
| work_keys_str_mv | AT erictoussirot theinfluenceofadipokinesonradiographicdamageininflammatoryrheumaticdiseases AT erictoussirot influenceofadipokinesonradiographicdamageininflammatoryrheumaticdiseases |