Advances in the application of 3D tumor models in precision oncology and drug screening
Traditional tumor models cannot perfectly simulate the real state of tumors in vivo, resulting in the termination of many clinical trials. 3D tumor models’ technology provides new in vitro models that bridge the gap between in vitro and in vivo findings, and organoids maintain the properties of the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1021966/full |
| _version_ | 1811208494581284864 |
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| author | Xiaoyong Guan Shigao Huang |
| author_facet | Xiaoyong Guan Shigao Huang |
| author_sort | Xiaoyong Guan |
| collection | DOAJ |
| description | Traditional tumor models cannot perfectly simulate the real state of tumors in vivo, resulting in the termination of many clinical trials. 3D tumor models’ technology provides new in vitro models that bridge the gap between in vitro and in vivo findings, and organoids maintain the properties of the original tissue over a long period of culture, which enables extensive research in this area. In addition, they can be used as a substitute for animal and in vitro models, and organoids can be established from patients’ normal and malignant tissues, with unique advantages in clinical drug development and in guiding individualized therapies. 3D tumor models also provide a promising platform for high-throughput research, drug and toxicity testing, disease modeling, and regenerative medicine. This report summarizes the 3D tumor model, including evidence regarding the 3D tumor cell culture model, 3D tumor slice model, and organoid culture model. In addition, it provides evidence regarding the application of 3D tumor organoid models in precision oncology and drug screening. The aim of this report is to elucidate the value of 3D tumor models in cancer research and provide a preclinical reference for the precise treatment of cancer patients. |
| first_indexed | 2024-04-12T04:22:25Z |
| format | Article |
| id | doaj.art-740f3a4b7cc44c40b4d0ec296ac9bb2e |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T04:22:25Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-740f3a4b7cc44c40b4d0ec296ac9bb2e2022-12-22T03:48:11ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.10219661021966Advances in the application of 3D tumor models in precision oncology and drug screeningXiaoyong Guan0Shigao Huang1Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital, Air Force Medical University, Xi’an, ChinaTraditional tumor models cannot perfectly simulate the real state of tumors in vivo, resulting in the termination of many clinical trials. 3D tumor models’ technology provides new in vitro models that bridge the gap between in vitro and in vivo findings, and organoids maintain the properties of the original tissue over a long period of culture, which enables extensive research in this area. In addition, they can be used as a substitute for animal and in vitro models, and organoids can be established from patients’ normal and malignant tissues, with unique advantages in clinical drug development and in guiding individualized therapies. 3D tumor models also provide a promising platform for high-throughput research, drug and toxicity testing, disease modeling, and regenerative medicine. This report summarizes the 3D tumor model, including evidence regarding the 3D tumor cell culture model, 3D tumor slice model, and organoid culture model. In addition, it provides evidence regarding the application of 3D tumor organoid models in precision oncology and drug screening. The aim of this report is to elucidate the value of 3D tumor models in cancer research and provide a preclinical reference for the precise treatment of cancer patients.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1021966/full3D tumor cell culture3D tumor sectioningantitumor drugs screeningtumor organoidsprecision oncology |
| spellingShingle | Xiaoyong Guan Shigao Huang Advances in the application of 3D tumor models in precision oncology and drug screening Frontiers in Bioengineering and Biotechnology 3D tumor cell culture 3D tumor sectioning antitumor drugs screening tumor organoids precision oncology |
| title | Advances in the application of 3D tumor models in precision oncology and drug screening |
| title_full | Advances in the application of 3D tumor models in precision oncology and drug screening |
| title_fullStr | Advances in the application of 3D tumor models in precision oncology and drug screening |
| title_full_unstemmed | Advances in the application of 3D tumor models in precision oncology and drug screening |
| title_short | Advances in the application of 3D tumor models in precision oncology and drug screening |
| title_sort | advances in the application of 3d tumor models in precision oncology and drug screening |
| topic | 3D tumor cell culture 3D tumor sectioning antitumor drugs screening tumor organoids precision oncology |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1021966/full |
| work_keys_str_mv | AT xiaoyongguan advancesintheapplicationof3dtumormodelsinprecisiononcologyanddrugscreening AT shigaohuang advancesintheapplicationof3dtumormodelsinprecisiononcologyanddrugscreening |