Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages

Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages

Antibody-dependent cellular phagocytosis (ADCP) by macrophages, an important effector function of tumor targeting antibodies, is hampered by ‘Don´t Eat Me!’ signals such as CD47 expressed by cancer cells. Yet, human leukocyte antigen (HLA) class I expression may also impair ADCP by engaging leukocyt...

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Bibliographic Details
Main Authors: Tobias Zeller, Sebastian Lutz, Ira A. Münnich, Roland Windisch, Patricia Hilger, Tobias Herold, Natyra Tahiri, Jan C. Banck, Oliver Weigert, Andreas Moosmann, Michael von Bergwelt-Baildon, Cindy Flamann, Heiko Bruns, Christian Wichmann, Niklas Baumann, Thomas Valerius, Denis M. Schewe, Matthias Peipp, Thies Rösner, Andreas Humpe, Christian Kellner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
antibody therapy
macrophages
phagocytosis
CD20
CD47
LILRB1 (ILT2)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.929339/full

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