Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population
This multi-center cohort study included 3401 myopic laser in situ keratomileusis (LASIK) procedures conducted in 1756 myopia patients between 2002 and 2005. Pre- and postoperative uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and manifest refraction spherical equivalent (SE)...
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MDPI AG
2021-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/5/419 |
| _version_ | 1797533883722366976 |
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| author | Jae-Yong Kim Hun Lee Choun-Ki Joo Joon-Young Hyon Tae-Im Kim Jin-Hyoung Kim Jin-Kuk Kim Eun-Young Cho Ji-Eun Choi Na-Rae Lee Hung-Won Tchah |
| author_facet | Jae-Yong Kim Hun Lee Choun-Ki Joo Joon-Young Hyon Tae-Im Kim Jin-Hyoung Kim Jin-Kuk Kim Eun-Young Cho Ji-Eun Choi Na-Rae Lee Hung-Won Tchah |
| author_sort | Jae-Yong Kim |
| collection | DOAJ |
| description | This multi-center cohort study included 3401 myopic laser in situ keratomileusis (LASIK) procedures conducted in 1756 myopia patients between 2002 and 2005. Pre- and postoperative uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and manifest refraction spherical equivalent (SE) were recorded. Factors predicting low postoperative efficacy (defined as a postoperative UCVA < 0.5) were identified using univariate and multivariate logistic regression analysis. Compared with 1 month postoperatively, logMAR UCVA at 3 months postoperatively was significantly decreased (<i>p</i> = 0.002) and that at 2 and 3 years was significantly increased (<i>p</i> < 0.001). LogMAR BCVA at 2 years postoperatively was significantly decreased compared with 1 month postoperatively (<i>p</i> = 0.008). Over the 3-year postoperative period, overall refractive predictability within ±1.00 D and ±0.50 D ranged from 69.0% to 86.2% and from 43.3% to 67.8%, respectively. This also decreased from 1 month to 6 months postoperatively (<i>p</i> < 0.005). Multivariate logistic regression analysis using generalized estimating equations, revealed that higher preoperative SE (odds ratio [OR], 2.58 and 7.23; <i>p</i> < 0.001) and lower preoperative BCVA (OR, 2.44; <i>p</i> = 0.003) were predictive of a low postoperative efficacy. In summary, myopic LASIK can be effective and safe with a high refractive predictability in a Korean population, but myopic regression occurs over time. Higher preoperative SE and lower preoperative BCVA are predictive of a low postoperative efficacy. |
| first_indexed | 2024-03-10T11:22:00Z |
| format | Article |
| id | doaj.art-7413dc402c66446396f055a8fee59e48 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T11:22:00Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-7413dc402c66446396f055a8fee59e482023-11-21T19:58:18ZengMDPI AGJournal of Personalized Medicine2075-44262021-05-0111541910.3390/jpm11050419Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean PopulationJae-Yong Kim0Hun Lee1Choun-Ki Joo2Joon-Young Hyon3Tae-Im Kim4Jin-Hyoung Kim5Jin-Kuk Kim6Eun-Young Cho7Ji-Eun Choi8Na-Rae Lee9Hung-Won Tchah10Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Ophthalmology and Visual Science, Kangnam St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Ophthalmology, Institute of Vision Research, Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Ophthalmology, Ilsan Paik Hospital, Inje University of Korea, Koyang 10380, KoreaB&VIIT Eye Center, Seoul 06615, KoreaB&VIIT Eye Center, Seoul 06615, KoreaNational Evidence-Based Healthcare Collaborating Agency, Seoul 04554, KoreaNational Evidence-Based Healthcare Collaborating Agency, Seoul 04554, KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaThis multi-center cohort study included 3401 myopic laser in situ keratomileusis (LASIK) procedures conducted in 1756 myopia patients between 2002 and 2005. Pre- and postoperative uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and manifest refraction spherical equivalent (SE) were recorded. Factors predicting low postoperative efficacy (defined as a postoperative UCVA < 0.5) were identified using univariate and multivariate logistic regression analysis. Compared with 1 month postoperatively, logMAR UCVA at 3 months postoperatively was significantly decreased (<i>p</i> = 0.002) and that at 2 and 3 years was significantly increased (<i>p</i> < 0.001). LogMAR BCVA at 2 years postoperatively was significantly decreased compared with 1 month postoperatively (<i>p</i> = 0.008). Over the 3-year postoperative period, overall refractive predictability within ±1.00 D and ±0.50 D ranged from 69.0% to 86.2% and from 43.3% to 67.8%, respectively. This also decreased from 1 month to 6 months postoperatively (<i>p</i> < 0.005). Multivariate logistic regression analysis using generalized estimating equations, revealed that higher preoperative SE (odds ratio [OR], 2.58 and 7.23; <i>p</i> < 0.001) and lower preoperative BCVA (OR, 2.44; <i>p</i> = 0.003) were predictive of a low postoperative efficacy. In summary, myopic LASIK can be effective and safe with a high refractive predictability in a Korean population, but myopic regression occurs over time. Higher preoperative SE and lower preoperative BCVA are predictive of a low postoperative efficacy.https://www.mdpi.com/2075-4426/11/5/419laser in situ keratomileusisefficacysafety |
| spellingShingle | Jae-Yong Kim Hun Lee Choun-Ki Joo Joon-Young Hyon Tae-Im Kim Jin-Hyoung Kim Jin-Kuk Kim Eun-Young Cho Ji-Eun Choi Na-Rae Lee Hung-Won Tchah Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population Journal of Personalized Medicine laser in situ keratomileusis efficacy safety |
| title | Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population |
| title_full | Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population |
| title_fullStr | Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population |
| title_full_unstemmed | Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population |
| title_short | Three-Year Follow-Up of Laser In Situ Keratomileusis Treatments for Myopia: Multi-Center Cohort Study in Korean Population |
| title_sort | three year follow up of laser in situ keratomileusis treatments for myopia multi center cohort study in korean population |
| topic | laser in situ keratomileusis efficacy safety |
| url | https://www.mdpi.com/2075-4426/11/5/419 |
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