In silico screening, pharmacokinetic, DFT, and dynamics simulation study of ant-hepatitis C virus compounds as potential NS5B Polymerase inhibitors

In silico screening, pharmacokinetic, DFT, and dynamics simulation study of ant-hepatitis C virus compounds as potential NS5B Polymerase inhibitors

Cirrhosis, hepatocellular carcinoma, and other serious liver diseases are caused by the hepatitis C virus (HCV) infection. An oral NS5B inhibitor for the therapy of HCV called Sofosbuvir has received approval. However, its high cost and numerous side effects are emphasized. Therefore, alternative HC...

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Bibliographic Details
Main Authors:	Stephen Ejeh, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi, Muhammad Tukur Ibrahim
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Series:	Scientific African
Subjects:	Drug kinetics Plant-derived molecules Eclipta alba
Online Access:	http://www.sciencedirect.com/science/article/pii/S2468227624000474

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