Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma
Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss. The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurode...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8068 |
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| author | Ryan G. Strickland Mary Anne Garner Alecia K. Gross Christopher A. Girkin |
| author_facet | Ryan G. Strickland Mary Anne Garner Alecia K. Gross Christopher A. Girkin |
| author_sort | Ryan G. Strickland |
| collection | DOAJ |
| description | Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss. The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurodegeneration. There are three major classes of cells in the human optic nerve head (ONH): lamina cribrosa (LC) cells, glial cells, and scleral fibroblasts. These cells provide support for the LC which is essential to maintain healthy retinal ganglion cell (RGC) axons. All these cells demonstrate responses to glaucomatous conditions through extracellular matrix remodeling. Therefore, investigations into alternative therapies that alter the characteristic remodeling response of the ONH to enhance the survival of RGC axons are prevalent. Understanding major remodeling pathways in the ONH may be key to developing targeted therapies that reduce deleterious remodeling. |
| first_indexed | 2024-03-09T05:24:21Z |
| format | Article |
| id | doaj.art-7417ddad3caa4190ac39b524450847d8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:24:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7417ddad3caa4190ac39b524450847d82023-12-03T12:38:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315806810.3390/ijms23158068Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for GlaucomaRyan G. Strickland0Mary Anne Garner1Alecia K. Gross2Christopher A. Girkin3Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Ophthalmology and Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USAGlaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss. The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurodegeneration. There are three major classes of cells in the human optic nerve head (ONH): lamina cribrosa (LC) cells, glial cells, and scleral fibroblasts. These cells provide support for the LC which is essential to maintain healthy retinal ganglion cell (RGC) axons. All these cells demonstrate responses to glaucomatous conditions through extracellular matrix remodeling. Therefore, investigations into alternative therapies that alter the characteristic remodeling response of the ONH to enhance the survival of RGC axons are prevalent. Understanding major remodeling pathways in the ONH may be key to developing targeted therapies that reduce deleterious remodeling.https://www.mdpi.com/1422-0067/23/15/8068glaucomaoptic nerve headlamina cribrosalamina cribrosa cellsscleral fibroblastsglial cells |
| spellingShingle | Ryan G. Strickland Mary Anne Garner Alecia K. Gross Christopher A. Girkin Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma International Journal of Molecular Sciences glaucoma optic nerve head lamina cribrosa lamina cribrosa cells scleral fibroblasts glial cells |
| title | Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma |
| title_full | Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma |
| title_fullStr | Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma |
| title_full_unstemmed | Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma |
| title_short | Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma |
| title_sort | remodeling of the lamina cribrosa mechanisms and potential therapeutic approaches for glaucoma |
| topic | glaucoma optic nerve head lamina cribrosa lamina cribrosa cells scleral fibroblasts glial cells |
| url | https://www.mdpi.com/1422-0067/23/15/8068 |
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