Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis
Background: To systematically analyze the influence of genetic polymorphisms of matrix metalloproteinase 9 (MMP9) on susceptibility to chronic obstructive pulmonary disease (COPD). Methods: Relevant literatures reporting MMP9 and susceptibility to COPD in PubMed, Web of Science, VIP, Wanfang and CNK...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2022-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582203263Y.pdf |
| _version_ | 1817997413895372800 |
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| author | Yang Xiaoping Yu Yuanyuan Wang Yong Jiang Wen Jiang Wenqing Yin Bin |
| author_facet | Yang Xiaoping Yu Yuanyuan Wang Yong Jiang Wen Jiang Wenqing Yin Bin |
| author_sort | Yang Xiaoping |
| collection | DOAJ |
| description | Background: To systematically analyze the influence of genetic polymorphisms of matrix metalloproteinase 9 (MMP9) on susceptibility to chronic obstructive pulmonary disease (COPD). Methods: Relevant literatures reporting MMP9 and susceptibility to COPD in PubMed, Web of Science, VIP, Wanfang and CNKI databases were searched using the key words "matrix metalloproteinases 9/MMP9, COPD/chronic obstructive pulmonary disease". Data of eligible literatures were extracted and analyzed for the odds ratio (OR) and corresponding 95% CI. Results: A total of 16 independent studies reporting MMP9-1562C/T and COPD patients were enrolled and analyzed. None of the genetic models revealed the relationship between MMP9-1562C/T and susceptibility to COPD. Subgroup analyses identified lower risk of COPD in Chinese population carrying the TT genotype for theMMP9 rs3918242 relative to those carrying CT and CC genotypes (P=0.03, OR=0.67, 95% CI=0.46-0.97). Conclusions: Chinese population carrying the TT genotype for the MMP-9 rs3918242 present lower susceptibility to COPD relative to those carrying CT and CC genotypes. |
| first_indexed | 2024-04-14T02:37:50Z |
| format | Article |
| id | doaj.art-7418309c883a454ba40fcb2cd5dae246 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-14T02:37:50Z |
| publishDate | 2022-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-7418309c883a454ba40fcb2cd5dae2462022-12-22T02:17:19ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662022-01-0141326327410.5937/jomb0-341551452-82582203263YGenetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysisYang Xiaoping0Yu Yuanyuan1Wang Yong2Jiang Wen3Jiang Wenqing4Yin Bin5Qingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, ChinaQingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department of Anesthesiology, Qingdao, ChinaQingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, ChinaQingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, ChinaQingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, ChinaQingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, ChinaBackground: To systematically analyze the influence of genetic polymorphisms of matrix metalloproteinase 9 (MMP9) on susceptibility to chronic obstructive pulmonary disease (COPD). Methods: Relevant literatures reporting MMP9 and susceptibility to COPD in PubMed, Web of Science, VIP, Wanfang and CNKI databases were searched using the key words "matrix metalloproteinases 9/MMP9, COPD/chronic obstructive pulmonary disease". Data of eligible literatures were extracted and analyzed for the odds ratio (OR) and corresponding 95% CI. Results: A total of 16 independent studies reporting MMP9-1562C/T and COPD patients were enrolled and analyzed. None of the genetic models revealed the relationship between MMP9-1562C/T and susceptibility to COPD. Subgroup analyses identified lower risk of COPD in Chinese population carrying the TT genotype for theMMP9 rs3918242 relative to those carrying CT and CC genotypes (P=0.03, OR=0.67, 95% CI=0.46-0.97). Conclusions: Chinese population carrying the TT genotype for the MMP-9 rs3918242 present lower susceptibility to COPD relative to those carrying CT and CC genotypes.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582203263Y.pdfmmp9polymorphismcopdmeta-analysis |
| spellingShingle | Yang Xiaoping Yu Yuanyuan Wang Yong Jiang Wen Jiang Wenqing Yin Bin Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis Journal of Medical Biochemistry mmp9 polymorphism copd meta-analysis |
| title | Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis |
| title_full | Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis |
| title_fullStr | Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis |
| title_full_unstemmed | Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis |
| title_short | Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis |
| title_sort | genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease a meta analysis |
| topic | mmp9 polymorphism copd meta-analysis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582203263Y.pdf |
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