Rapid-Onset Anti-Stress Effects of a Kappa-Opioid Receptor Antagonist, LY2795050, Against Immobility in an Open Space Swim Paradigm in Male and Female Mice

Rapid-Onset Anti-Stress Effects of a Kappa-Opioid Receptor Antagonist, LY2795050, Against Immobility in an Open Space Swim Paradigm in Male and Female Mice

The kappa-opioid receptor (KOR) / dynorphin system is implicated with behavioral and neurobiological effects of stress exposure (including heavy exposure to drugs of abuse) in translational animal models. Thus some KOR-antagonists can decrease the aversive, depressant-like and anxiety-like effects c...

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Bibliographic Details
Main Authors:	Caroline Baynard, Thomas E. Prisinzano, Eduardo R. Butelman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-11-01
Series:	Frontiers in Pharmacology
Subjects:	open space swim kappa-opioid receptor stress acute stress disorder dynorphin
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.775317/full

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