Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012
Abstract Background: A surgical site infection (SSI) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. The aim of this study was to asses minimum inhibitory concentration (MIC) of the causing agents of SSI and antimicrobial suscept...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2015-01-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/browse.php?a_code=A-10-1-16&slc_lang=en&sid=1 |
| _version_ | 1811233663505924096 |
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| author | Ahmad Alikhani Farhang Babamahmoodi Laleh Foroutan Alizadegan Arman Shojaeefar Abdolreza Babamahmoodi |
| author_facet | Ahmad Alikhani Farhang Babamahmoodi Laleh Foroutan Alizadegan Arman Shojaeefar Abdolreza Babamahmoodi |
| author_sort | Ahmad Alikhani |
| collection | DOAJ |
| description | Abstract
Background: A surgical site infection (SSI) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. The aim of this study was to asses minimum inhibitory concentration (MIC) of the causing agents of SSI and antimicrobial susceptibility patterns.
Methods: This cross-sectional study was done in three referral hospitals in North of Iran during 2011-2012. The samples were taken one month after orthopedic, abdominal, cesarean section surgery and coronary artery bypass graft (CABG) in patients with scores compatible to SSIs criteria. The sample was sent for bacteriologic culture and MIC determination for positive cases by broth microdilution method. The data were collected and analyzed.
Results: From 103 positive cases S. aureus, E.coli and coagulase negative staphylococci were the most common isolated agents as 29.12%, 23.3% and 21.3%, respectively. S. aureus was sensitive to vancomycin (70%), amikacin (70%) and teicoplanin (76.6%) and cogulase negative staphylococci was sensitive to vancomycin (68.1%) and teicoplanin (72.6%) and E.coli to amikacin (95.83%) and imipenem and meropenem (66.66%). P.aeroginosa showed no sensitivity to cefepime and was sensitive to imipenem (93.75%) and meropenem (81.25%).
Conclusion: The most important point is worrisome problem of the increased MIC of S. aureus to vancomycin that causes difficult use in the treatment of staphylococcal SSIs. In spite of resistance of micro-organisms to cephalosporins, gram negative organisms had low MIC to carbapenemes especially P.aeroginosa although the rate of its MIC is increasing. |
| first_indexed | 2024-04-12T11:23:23Z |
| format | Article |
| id | doaj.art-741a54a623fb4c39acc604adb5985f35 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-04-12T11:23:23Z |
| publishDate | 2015-01-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-741a54a623fb4c39acc604adb5985f352022-12-22T03:35:18ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722015-01-01613439Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012Ahmad Alikhani0Farhang Babamahmoodi1Laleh Foroutan Alizadegan2Arman Shojaeefar3Abdolreza Babamahmoodi4 Department of Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Department of Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Mazandaran University of Medical Sciences, Sari, Iran. Ghaemshahr Razi Hospital, Ghaemshahr, Iran Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Abstract Background: A surgical site infection (SSI) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. The aim of this study was to asses minimum inhibitory concentration (MIC) of the causing agents of SSI and antimicrobial susceptibility patterns. Methods: This cross-sectional study was done in three referral hospitals in North of Iran during 2011-2012. The samples were taken one month after orthopedic, abdominal, cesarean section surgery and coronary artery bypass graft (CABG) in patients with scores compatible to SSIs criteria. The sample was sent for bacteriologic culture and MIC determination for positive cases by broth microdilution method. The data were collected and analyzed. Results: From 103 positive cases S. aureus, E.coli and coagulase negative staphylococci were the most common isolated agents as 29.12%, 23.3% and 21.3%, respectively. S. aureus was sensitive to vancomycin (70%), amikacin (70%) and teicoplanin (76.6%) and cogulase negative staphylococci was sensitive to vancomycin (68.1%) and teicoplanin (72.6%) and E.coli to amikacin (95.83%) and imipenem and meropenem (66.66%). P.aeroginosa showed no sensitivity to cefepime and was sensitive to imipenem (93.75%) and meropenem (81.25%). Conclusion: The most important point is worrisome problem of the increased MIC of S. aureus to vancomycin that causes difficult use in the treatment of staphylococcal SSIs. In spite of resistance of micro-organisms to cephalosporins, gram negative organisms had low MIC to carbapenemes especially P.aeroginosa although the rate of its MIC is increasing.http://caspjim.com/browse.php?a_code=A-10-1-16&slc_lang=en&sid=1Minimal Inhibitory Concentration Surgical site infection Resistance Antibiotics |
| spellingShingle | Ahmad Alikhani Farhang Babamahmoodi Laleh Foroutan Alizadegan Arman Shojaeefar Abdolreza Babamahmoodi Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012 Caspian Journal of Internal Medicine Minimal Inhibitory Concentration Surgical site infection Resistance Antibiotics |
| title | Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012 |
| title_full | Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012 |
| title_fullStr | Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012 |
| title_full_unstemmed | Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012 |
| title_short | Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012 |
| title_sort | minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in north of iran 2011 2012 |
| topic | Minimal Inhibitory Concentration Surgical site infection Resistance Antibiotics |
| url | http://caspjim.com/browse.php?a_code=A-10-1-16&slc_lang=en&sid=1 |
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