Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model
Background: Aloe Vera contains many inorganic electrolytes like iron, potassium, chromium, copper, sodium, calcium, and zinc that are vital parts that induced the wound healing process as a result of the ability to prevent injury to the epithelium and promote healing of injured tissues. It improves...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2021-10-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/835 |
| _version_ | 1797530872931418112 |
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| author | Amal Hanna Aziz |
| author_facet | Amal Hanna Aziz |
| author_sort | Amal Hanna Aziz |
| collection | DOAJ |
| description |
Background: Aloe Vera contains many inorganic electrolytes like iron, potassium, chromium, copper, sodium, calcium, and zinc that are vital parts that induced the wound healing process as a result of the ability to prevent injury to the epithelium and promote healing of injured tissues. It improves healing by increasing the blood supply and oxygen to the area of injury tissue.
Objective: To evaluate the anti-inflammatory effect of Aloe Vera on wound healing in rats with full thickness flap and insertion of Aloe vera gel at the site of injury throughout analysis of the activity level of serum interleukin-1beta (IL-1β).
Patients and Methods: Fifty five male rats were randomly divided into three groups: A-Aloe vera gel (25 rats), subdivided into (5) subgroups as a test group, B- Chlorhexidine gel (25 rats) was also subdivided randomly into (5) subgroups as a test group. Each subgroup (5rats) was exposed to surgery and filled with (AV) and CHX gel in both. C-non-surgical control group (5 rats) to obtain baseline data. A sulcular full thickness flap incision was carried out between the two maxillary central incisors. Blood samples for immunological studies were collected by cardiac puncture, at times (3, 5, 7, 10, and14 days) for estimation of serum (IL-1β) levels using Indirect ELISA Technique in all groups.
Results: A highly significant decrease of serum IL-1β in rat group (A) within 3 and 5days post-surgery, then the concentration of this cytokine started to increase on 7,10and 14days post-surgery, which is statistically non significantly affect with the control group (C), where it reaches the level of the control level before surgery.
Conclusion: Aloe vera shows anti-inflammatory effects by decreasing the inflammation of periodontal tissue post-surgery which could accelerate healing based on a significant increase in the level of serum (IL-1β), reaching the control level before surgery at 14days, post-surgery that indicated positive results of this study.
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| first_indexed | 2024-03-10T10:35:12Z |
| format | Article |
| id | doaj.art-741b512d92b8446daec0d7704855a2ae |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-10T10:35:12Z |
| publishDate | 2021-10-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-741b512d92b8446daec0d7704855a2ae2023-11-21T23:20:37ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822021-10-01211Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats ModelAmal Hanna Aziz Background: Aloe Vera contains many inorganic electrolytes like iron, potassium, chromium, copper, sodium, calcium, and zinc that are vital parts that induced the wound healing process as a result of the ability to prevent injury to the epithelium and promote healing of injured tissues. It improves healing by increasing the blood supply and oxygen to the area of injury tissue. Objective: To evaluate the anti-inflammatory effect of Aloe Vera on wound healing in rats with full thickness flap and insertion of Aloe vera gel at the site of injury throughout analysis of the activity level of serum interleukin-1beta (IL-1β). Patients and Methods: Fifty five male rats were randomly divided into three groups: A-Aloe vera gel (25 rats), subdivided into (5) subgroups as a test group, B- Chlorhexidine gel (25 rats) was also subdivided randomly into (5) subgroups as a test group. Each subgroup (5rats) was exposed to surgery and filled with (AV) and CHX gel in both. C-non-surgical control group (5 rats) to obtain baseline data. A sulcular full thickness flap incision was carried out between the two maxillary central incisors. Blood samples for immunological studies were collected by cardiac puncture, at times (3, 5, 7, 10, and14 days) for estimation of serum (IL-1β) levels using Indirect ELISA Technique in all groups. Results: A highly significant decrease of serum IL-1β in rat group (A) within 3 and 5days post-surgery, then the concentration of this cytokine started to increase on 7,10and 14days post-surgery, which is statistically non significantly affect with the control group (C), where it reaches the level of the control level before surgery. Conclusion: Aloe vera shows anti-inflammatory effects by decreasing the inflammation of periodontal tissue post-surgery which could accelerate healing based on a significant increase in the level of serum (IL-1β), reaching the control level before surgery at 14days, post-surgery that indicated positive results of this study. https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/835Aloe Vera, chlorhexidine, pro-inflammatory (IL-1β), surgical full thickness flap |
| spellingShingle | Amal Hanna Aziz Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model Diyala Journal of Medicine Aloe Vera, chlorhexidine, pro-inflammatory (IL-1β), surgical full thickness flap |
| title | Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model |
| title_full | Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model |
| title_fullStr | Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model |
| title_full_unstemmed | Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model |
| title_short | Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model |
| title_sort | evaluation the anti inflammatory effect of prepared aloe vera gel in sulcular full thickness flap induced in rats model |
| topic | Aloe Vera, chlorhexidine, pro-inflammatory (IL-1β), surgical full thickness flap |
| url | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/835 |
| work_keys_str_mv | AT amalhannaaziz evaluationtheantiinflammatoryeffectofpreparedaloeveragelinsulcularfullthicknessflapinducedinratsmodel |