Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves
Background: To determine the antimicrobial, antiproliferative and antioxidant activities of ethanolic, ethyl acetate and petroleum ether extracts of Psidiumguajava leaves. Methods: The antimicrobial activity was assessed using disc diffusion method on Staphylococcus aureus, Bacillus cereus, Klebsiel...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2016-09-01
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| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/183 |
| _version_ | 1818146230821191680 |
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| author | Adeel Zafar |
| author_facet | Adeel Zafar |
| author_sort | Adeel Zafar |
| collection | DOAJ |
| description | Background: To determine the antimicrobial, antiproliferative
and antioxidant activities of ethanolic,
ethyl acetate and petroleum ether extracts of
Psidiumguajava leaves.
Methods: The antimicrobial activity was assessed
using disc diffusion method on Staphylococcus
aureus, Bacillus cereus, Klebsiella pneumoniae,
Pseudomonas aeruginosa, Escherichia coli and
Salmonella typhi. The anti-proliferative activity was
determined on HeLa cell lines. The anti-proliferative
activity was assessed using MTT assay while
antioxidant activity was determined using catalase
and superoxide dismutase (SOD) assays.
Results: The MTT results indicate that ethyl acetate
and petroleum ether extracts have significantly
inhibited the proliferation of HeLa cells as compared
to the control. Antioxidant assays showed that
catalase activity was insignificant for all extracts
however the SOD activity was significant. All the
extracts showed inhibitory zones against B. cereus
while only ethanolic extract of P. guajava leaves was
active against S. aureus.
Conclusion: Psidiumguajava plant leaves extracts
can be used as antiproliferative agent against HeLa
cell line |
| first_indexed | 2024-12-11T12:16:03Z |
| format | Article |
| id | doaj.art-741b529d4b6147abb7d8f818946b5869 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-11T12:16:03Z |
| publishDate | 2016-09-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-741b529d4b6147abb7d8f818946b58692022-12-22T01:07:39ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702016-09-01203Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava LeavesAdeel Zafar01.Department of Pathology, The University of LahoreBackground: To determine the antimicrobial, antiproliferative and antioxidant activities of ethanolic, ethyl acetate and petroleum ether extracts of Psidiumguajava leaves. Methods: The antimicrobial activity was assessed using disc diffusion method on Staphylococcus aureus, Bacillus cereus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi. The anti-proliferative activity was determined on HeLa cell lines. The anti-proliferative activity was assessed using MTT assay while antioxidant activity was determined using catalase and superoxide dismutase (SOD) assays. Results: The MTT results indicate that ethyl acetate and petroleum ether extracts have significantly inhibited the proliferation of HeLa cells as compared to the control. Antioxidant assays showed that catalase activity was insignificant for all extracts however the SOD activity was significant. All the extracts showed inhibitory zones against B. cereus while only ethanolic extract of P. guajava leaves was active against S. aureus. Conclusion: Psidiumguajava plant leaves extracts can be used as antiproliferative agent against HeLa cell linehttps://www.journalrmc.com/index.php/JRMC/article/view/183Psidiumguajava leavesantioxidant,antiproliferative |
| spellingShingle | Adeel Zafar Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves Journal of Rawalpindi Medical College Psidiumguajava leaves antioxidant, antiproliferative |
| title | Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves |
| title_full | Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves |
| title_fullStr | Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves |
| title_full_unstemmed | Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves |
| title_short | Antimicrobial, Antiproliferative and Antioxidant Activities of Eethanolic, Ethyl Acetate and Petroleum Ether Extracts of PsidiumGuajava Leaves |
| title_sort | antimicrobial antiproliferative and antioxidant activities of eethanolic ethyl acetate and petroleum ether extracts of psidiumguajava leaves |
| topic | Psidiumguajava leaves antioxidant, antiproliferative |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/183 |
| work_keys_str_mv | AT adeelzafar antimicrobialantiproliferativeandantioxidantactivitiesofeethanolicethylacetateandpetroleumetherextractsofpsidiumguajavaleaves |