Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy
Summary: Arthritic diseases have attracted enormous scientific interest because of increased worldwide prevalence and represent a significant socioeconomic burden. Osteoarthritis (OA) is the most prevalent form of arthritis. It is a disorder of the diarthrodial joints, characterized by degeneration...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422201820X |
| _version_ | 1798016196962942976 |
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| author | Sergio Ramirez-Perez Itzel Viridiana Reyes-Perez Diana Emilia Martinez-Fernandez Luis Alexis Hernandez-Palma Pallavi Bhattaram |
| author_facet | Sergio Ramirez-Perez Itzel Viridiana Reyes-Perez Diana Emilia Martinez-Fernandez Luis Alexis Hernandez-Palma Pallavi Bhattaram |
| author_sort | Sergio Ramirez-Perez |
| collection | DOAJ |
| description | Summary: Arthritic diseases have attracted enormous scientific interest because of increased worldwide prevalence and represent a significant socioeconomic burden. Osteoarthritis (OA) is the most prevalent form of arthritis. It is a disorder of the diarthrodial joints, characterized by degeneration and loss of articular cartilage associated with adjacent subchondral bone changes. Chronic and unresolving inflammation has been identified as a critical factor driving joint degeneration and pain in OA. Despite numerous attempts at therapeutic intervention, no effective disease-modifying agents targeting OA inflammation are available to the patients. Inflammasomes are protein complexes known to play a critical role in the inflammatory pathology of several diseases, and their roles in OA pathogenesis have become evident over the last decade. In this sense, it is relevant to evaluate the vital role of inflammasomes as potential modulators of pathogenic features in OA. This review will provide an overview and perspectives on why understanding inflammasome activation is critical for identifying effective OA therapies. We elaborate on the contribution of extracellular mediators from the circulatory system and synovial fluid as well as intracellular activators within the synovial fibroblasts and articular chondrocytes toward invoking the inflammasome in OA. We further discuss the merits of emerging inflammasome targeting therapies and speculate on the potential strategies for inflammasome blockade for OA therapy. |
| first_indexed | 2024-04-11T15:45:41Z |
| format | Article |
| id | doaj.art-741c8dd943a44d559228d6f29595e3a8 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-11T15:45:41Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-741c8dd943a44d559228d6f29595e3a82022-12-22T04:15:31ZengElsevieriScience2589-00422022-12-012512105548Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapySergio Ramirez-Perez0Itzel Viridiana Reyes-Perez1Diana Emilia Martinez-Fernandez2Luis Alexis Hernandez-Palma3Pallavi Bhattaram4Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Musculoskeletal Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Corresponding authorDepartamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco 44340, MéxicoDepartamento de Farmacobiología, Centro Universitario de Ciencias Exactas e ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco 44430, MéxicoInstituto de Investigaciones en Comportamiento Alimentario y Nutrición (IICAN), Centro Universitario del Sur, Universidad de Guadalajara, Guadalajara, Jalisco 49000, México; Instituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco 44340, MéxicoDepartment of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Musculoskeletal Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Corresponding authorSummary: Arthritic diseases have attracted enormous scientific interest because of increased worldwide prevalence and represent a significant socioeconomic burden. Osteoarthritis (OA) is the most prevalent form of arthritis. It is a disorder of the diarthrodial joints, characterized by degeneration and loss of articular cartilage associated with adjacent subchondral bone changes. Chronic and unresolving inflammation has been identified as a critical factor driving joint degeneration and pain in OA. Despite numerous attempts at therapeutic intervention, no effective disease-modifying agents targeting OA inflammation are available to the patients. Inflammasomes are protein complexes known to play a critical role in the inflammatory pathology of several diseases, and their roles in OA pathogenesis have become evident over the last decade. In this sense, it is relevant to evaluate the vital role of inflammasomes as potential modulators of pathogenic features in OA. This review will provide an overview and perspectives on why understanding inflammasome activation is critical for identifying effective OA therapies. We elaborate on the contribution of extracellular mediators from the circulatory system and synovial fluid as well as intracellular activators within the synovial fibroblasts and articular chondrocytes toward invoking the inflammasome in OA. We further discuss the merits of emerging inflammasome targeting therapies and speculate on the potential strategies for inflammasome blockade for OA therapy.http://www.sciencedirect.com/science/article/pii/S258900422201820XHealth sciencesBiological sciencesPhysiology |
| spellingShingle | Sergio Ramirez-Perez Itzel Viridiana Reyes-Perez Diana Emilia Martinez-Fernandez Luis Alexis Hernandez-Palma Pallavi Bhattaram Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy iScience Health sciences Biological sciences Physiology |
| title | Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy |
| title_full | Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy |
| title_fullStr | Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy |
| title_full_unstemmed | Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy |
| title_short | Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy |
| title_sort | targeting inflammasome dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy |
| topic | Health sciences Biological sciences Physiology |
| url | http://www.sciencedirect.com/science/article/pii/S258900422201820X |
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