A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

Abstract Background Gastric cancer is the leading cause of cancer related death worldwide. Radiation alone or combined with chemotherapy plays important role in locally advanced and metastatic gastric adenocarcinoma. MDM2–p53 interaction and downstream signaling affect cellular response to DNA damag...

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Bibliographic Details
Main Authors: Hanjie Yi, Xianglei Yan, Qiuyun Luo, Luping Yuan, Baoxia Li, Wentao Pan, Lin Zhang, Haibo Chen, Jing Wang, Yubin Zhang, Yifan Zhai, Miao-Zhen Qiu, Da-Jun Yang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Small molecule inhibitors
MDM2
p53
Gastric cancer
Radiation
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13046-018-0765-8

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