Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis
ObjectivesThe specific benefits of a contralateral cervical 7 nerve transplant in people with spastic paralysis of the upper extremity caused by cerebral nerve injury are unclear. To evaluate the efficacy and safety of contralateral C7 nerve transfer for central spastic paralysis of the upper extrem...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1113254/full |
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| author | WenMiao Luo WenMiao Luo ZhengCun Yan Yu Guo Ji Xu Ji Xu Heng-Zhu Zhang Heng-Zhu Zhang |
| author_facet | WenMiao Luo WenMiao Luo ZhengCun Yan Yu Guo Ji Xu Ji Xu Heng-Zhu Zhang Heng-Zhu Zhang |
| author_sort | WenMiao Luo |
| collection | DOAJ |
| description | ObjectivesThe specific benefits of a contralateral cervical 7 nerve transplant in people with spastic paralysis of the upper extremity caused by cerebral nerve injury are unclear. To evaluate the efficacy and safety of contralateral C7 nerve transfer for central spastic paralysis of the upper extremity, we conducted a comprehensive literature search and meta-analysis.Materials and methodsPRISMA guidelines were used to search the databases for papers comparing the efficacy of contralateral cervical 7 nerve transfer vs. rehabilitation treatment from January 2010 to August 2022. The finishing indications were expressed using SMD ± mean. A meta-analysis was used to assess the recovery of motor function in the paralyzed upper extremity.ResultsThe meta-analysis included three publications. One of the publications offers information about RCTs and non-RCTs. A total of 384 paralyzed patients were included, including 192 who underwent CC7 transfer and 192 who received rehabilitation. Results from all patients were combined and revealed that patients who had CC7 transfer may have regained greater motor function in the Fugl-Meyer score (SMD 3.52, 95% CI = 3.19–3.84, p < 0.00001) and had superior improvement in range of motion compared to the rehabilitation group (SMD 2.88, 95% CI = 2.47–3.29, p < 0.00001). In addition, the spasticity in the paralyzed upper extremity significantly improved in patients with CC7 transfer (SMD −1.42, 95% CI = −1.60 to −1.25, p < 0.00001).ConclusionOur findings suggested that a contralateral C7 nerve transfer, which has no additional adverse effects on the healthy upper limb, is a preferable method to restore motor function. |
| first_indexed | 2024-03-12T14:25:18Z |
| format | Article |
| id | doaj.art-741cf58edb8e4de9a27d2619cc667660 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T14:25:18Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-741cf58edb8e4de9a27d2619cc6676602023-08-18T08:07:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.11132541113254Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysisWenMiao Luo0WenMiao Luo1ZhengCun Yan2Yu Guo3Ji Xu4Ji Xu5Heng-Zhu Zhang6Heng-Zhu Zhang7Northern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Neurosurgery, The Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou, ChinaDepartment of Neurosurgery, The Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou, ChinaDepartment of Neurosurgery, The Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou, ChinaNorthern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Neurosurgery, The Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou, ChinaNorthern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Neurosurgery, The Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou, ChinaObjectivesThe specific benefits of a contralateral cervical 7 nerve transplant in people with spastic paralysis of the upper extremity caused by cerebral nerve injury are unclear. To evaluate the efficacy and safety of contralateral C7 nerve transfer for central spastic paralysis of the upper extremity, we conducted a comprehensive literature search and meta-analysis.Materials and methodsPRISMA guidelines were used to search the databases for papers comparing the efficacy of contralateral cervical 7 nerve transfer vs. rehabilitation treatment from January 2010 to August 2022. The finishing indications were expressed using SMD ± mean. A meta-analysis was used to assess the recovery of motor function in the paralyzed upper extremity.ResultsThe meta-analysis included three publications. One of the publications offers information about RCTs and non-RCTs. A total of 384 paralyzed patients were included, including 192 who underwent CC7 transfer and 192 who received rehabilitation. Results from all patients were combined and revealed that patients who had CC7 transfer may have regained greater motor function in the Fugl-Meyer score (SMD 3.52, 95% CI = 3.19–3.84, p < 0.00001) and had superior improvement in range of motion compared to the rehabilitation group (SMD 2.88, 95% CI = 2.47–3.29, p < 0.00001). In addition, the spasticity in the paralyzed upper extremity significantly improved in patients with CC7 transfer (SMD −1.42, 95% CI = −1.60 to −1.25, p < 0.00001).ConclusionOur findings suggested that a contralateral C7 nerve transfer, which has no additional adverse effects on the healthy upper limb, is a preferable method to restore motor function.https://www.frontiersin.org/articles/10.3389/fneur.2023.1113254/fullmeta-analysisrehabilitation therapyrecoverystrokesurgery |
| spellingShingle | WenMiao Luo WenMiao Luo ZhengCun Yan Yu Guo Ji Xu Ji Xu Heng-Zhu Zhang Heng-Zhu Zhang Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis Frontiers in Neurology meta-analysis rehabilitation therapy recovery stroke surgery |
| title | Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis |
| title_full | Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis |
| title_fullStr | Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis |
| title_full_unstemmed | Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis |
| title_short | Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis |
| title_sort | contralateral seventh cervical nerve transfer for central spastic arm paralysis a systematic review and meta analysis |
| topic | meta-analysis rehabilitation therapy recovery stroke surgery |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1113254/full |
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