Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

Abstract Background Endoplasmic reticulum (ER)-associated degradation (ERAD) regulates protein homeostasis in the secretory pathway by targeting misfolded or unassembled proteins for degradation by the proteasome. Hrd1 is a conserved multi-spanning membrane bound ubiquitin ligase required for ubiqui...

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Bibliographic Details
Main Authors: Yilin Ye, Suk-Hwan Baek, Yihong Ye, Ting Zhang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cell & Bioscience
Subjects:
Endoplasmic reticulum-associated protein degradation/ERAD
Protein quality control
OS9
ER stress
ERAD tuning
Lysosome degradation
Online Access:http://link.springer.com/article/10.1186/s13578-018-0245-z

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