Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis
Bacterial keratitis (BK) is an acute infection of the cornea, accompanied by uneven epithelium boundaries with stromal ulceration, potentially resulting in vision loss. Topical antibiotic is the regular treatment for BK. However, the incidence rate of multidrug-resistant bacteria limits the applicat...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1088935/full |
| _version_ | 1797961482960371712 |
|---|---|
| author | Wenting Cai Tianyi Shen Dong Wang Tingting Li Jing Yu Chen Peng Chen Peng Ben Zhong Tang Ben Zhong Tang |
| author_facet | Wenting Cai Tianyi Shen Dong Wang Tingting Li Jing Yu Chen Peng Chen Peng Ben Zhong Tang Ben Zhong Tang |
| author_sort | Wenting Cai |
| collection | DOAJ |
| description | Bacterial keratitis (BK) is an acute infection of the cornea, accompanied by uneven epithelium boundaries with stromal ulceration, potentially resulting in vision loss. Topical antibiotic is the regular treatment for BK. However, the incidence rate of multidrug-resistant bacteria limits the application of traditional antibiotics. Therefore, a cationic aggregation-induced emission luminogens (AIEgens) named TTVP is utilized for the treatment of BK. TTVP showed no obvious cytotoxicity in maintaining the normal cell morphology and viability under a limited concentration, and revealed the ability to selectively combine with bacteria in normal ocular environment. After light irradiation, TTVP produced reactive oxygen species (ROS), thus exerting efficient antibacterial ability in vitro. What’s more, in rat models of Staphylococcus aureus (S. aureus) infection, the therapeutic intervention of TTVP lessens the degree of corneal opacity and inflammatory infiltration, limiting the spread of inflammation. Besides, TTVP manifested superior antibacterial efficacy than levofloxacin in acute BK, endowing its better vision salvage ability than conventional method. This research demonstrates the efficacy and advantages of TTVP as a photodynamic drug in the treatment of BK and represents its promise in clinical application of ocular infections. |
| first_indexed | 2024-04-11T00:59:49Z |
| format | Article |
| id | doaj.art-74209518df56407d91347c060c709848 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T00:59:49Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-74209518df56407d91347c060c7098482023-01-04T18:36:53ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-01-011010.3389/fchem.2022.10889351088935Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitisWenting Cai0Tianyi Shen1Dong Wang2Tingting Li3Jing Yu4Chen Peng5Chen Peng6Ben Zhong Tang7Ben Zhong Tang8Department of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaCollege of Materials Science and Engineering, Shenzhen University, Shenzhen, ChinaDepartment of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaCollege of Materials Science and Engineering, Shenzhen University, Shenzhen, ChinaShenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Hong Kong SAR, ChinaBacterial keratitis (BK) is an acute infection of the cornea, accompanied by uneven epithelium boundaries with stromal ulceration, potentially resulting in vision loss. Topical antibiotic is the regular treatment for BK. However, the incidence rate of multidrug-resistant bacteria limits the application of traditional antibiotics. Therefore, a cationic aggregation-induced emission luminogens (AIEgens) named TTVP is utilized for the treatment of BK. TTVP showed no obvious cytotoxicity in maintaining the normal cell morphology and viability under a limited concentration, and revealed the ability to selectively combine with bacteria in normal ocular environment. After light irradiation, TTVP produced reactive oxygen species (ROS), thus exerting efficient antibacterial ability in vitro. What’s more, in rat models of Staphylococcus aureus (S. aureus) infection, the therapeutic intervention of TTVP lessens the degree of corneal opacity and inflammatory infiltration, limiting the spread of inflammation. Besides, TTVP manifested superior antibacterial efficacy than levofloxacin in acute BK, endowing its better vision salvage ability than conventional method. This research demonstrates the efficacy and advantages of TTVP as a photodynamic drug in the treatment of BK and represents its promise in clinical application of ocular infections.https://www.frontiersin.org/articles/10.3389/fchem.2022.1088935/fullaggregation-induced emission (AIE)bacterial keratitisStaphylococcus aureusantimicrobial materialsphotodynamic therapy |
| spellingShingle | Wenting Cai Tianyi Shen Dong Wang Tingting Li Jing Yu Chen Peng Chen Peng Ben Zhong Tang Ben Zhong Tang Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis Frontiers in Chemistry aggregation-induced emission (AIE) bacterial keratitis Staphylococcus aureus antimicrobial materials photodynamic therapy |
| title | Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis |
| title_full | Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis |
| title_fullStr | Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis |
| title_full_unstemmed | Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis |
| title_short | Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis |
| title_sort | efficient antibacterial aiegens induced ros for selective photodynamic treatment of bacterial keratitis |
| topic | aggregation-induced emission (AIE) bacterial keratitis Staphylococcus aureus antimicrobial materials photodynamic therapy |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1088935/full |
| work_keys_str_mv | AT wentingcai efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT tianyishen efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT dongwang efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT tingtingli efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT jingyu efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT chenpeng efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT chenpeng efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT benzhongtang efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis AT benzhongtang efficientantibacterialaiegensinducedrosforselectivephotodynamictreatmentofbacterialkeratitis |