Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication)
Abstract A post hoc analysis was performed using data obtained over eight weeks from 200 Japanese patients with schizophrenia who were switched to brexpiprazole monotherapy in a long‐term treatment study. The 8‐week period comprised of a 4‐week switching phase and a 4‐week post‐switch phase. For the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12107 |
| _version_ | 1811206096748019712 |
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| author | Jun Ishigooka Tomohiro Usami Shuichi Iwashita Yoshitsugu Kojima Satoshi Matsuo |
| author_facet | Jun Ishigooka Tomohiro Usami Shuichi Iwashita Yoshitsugu Kojima Satoshi Matsuo |
| author_sort | Jun Ishigooka |
| collection | DOAJ |
| description | Abstract A post hoc analysis was performed using data obtained over eight weeks from 200 Japanese patients with schizophrenia who were switched to brexpiprazole monotherapy in a long‐term treatment study. The 8‐week period comprised of a 4‐week switching phase and a 4‐week post‐switch phase. For the antipsychotic switching schedule, brexpiprazole was first administered at 1 mg/day and increased to 2 mg/day by the end of week 4. Concurrently, the previous antipsychotic(s) was/were tapered gradually from the start of week 3 and discontinued by the end of week 4. Brexpiprazole could then be increased up to 4 mg/day according to the CGI‐I criteria. At week 8, 1.8%, 23.2%, 25.0%, and 50% of patients were administered daily brexpiprazole doses of 1, 2, 3, and 4 mg, respectively. The discontinuation rate at week 8 was 17.0%. The major reasons for discontinuation were consent withdrawal (9.5%), occurrence of adverse events (5.5%), and physician's decision (2.0%). Commonly reported adverse events were nasopharyngitis (13.5%), schizophrenia (9.0%), insomnia (6.5%), headache (5.5%), and akathisia (5.5%). The discontinuation rate was 4.9% for patients who were switched from aripiprazole as the primary antipsychotic and 25.4% for those who were switched from other antipsychotics. Owing to the serious adverse events that led to treatment discontinuation, careful switching to brexpiprazole is necessary in patients who previously used olanzapine as their primary antipsychotic. |
| first_indexed | 2024-04-12T03:41:02Z |
| format | Article |
| id | doaj.art-74235da9f2b9452698f105852d1a929a |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-12T03:41:02Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-74235da9f2b9452698f105852d1a929a2022-12-22T03:49:16ZengWileyNeuropsychopharmacology Reports2574-173X2020-06-0140212212910.1002/npr2.12107Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication)Jun Ishigooka0Tomohiro Usami1Shuichi Iwashita2Yoshitsugu Kojima3Satoshi Matsuo4Tokyo Women’s Medical University Tokyo JapanMedical Affairs Otsuka Pharmaceutical Co., Ltd. Tokyo JapanHeadquarters of Clinical Development Otsuka Pharmaceutical Co., Ltd. Osaka JapanMedical Affairs Otsuka Pharmaceutical Co., Ltd. Tokyo JapanMedical Affairs Otsuka Pharmaceutical Co., Ltd. Osaka JapanAbstract A post hoc analysis was performed using data obtained over eight weeks from 200 Japanese patients with schizophrenia who were switched to brexpiprazole monotherapy in a long‐term treatment study. The 8‐week period comprised of a 4‐week switching phase and a 4‐week post‐switch phase. For the antipsychotic switching schedule, brexpiprazole was first administered at 1 mg/day and increased to 2 mg/day by the end of week 4. Concurrently, the previous antipsychotic(s) was/were tapered gradually from the start of week 3 and discontinued by the end of week 4. Brexpiprazole could then be increased up to 4 mg/day according to the CGI‐I criteria. At week 8, 1.8%, 23.2%, 25.0%, and 50% of patients were administered daily brexpiprazole doses of 1, 2, 3, and 4 mg, respectively. The discontinuation rate at week 8 was 17.0%. The major reasons for discontinuation were consent withdrawal (9.5%), occurrence of adverse events (5.5%), and physician's decision (2.0%). Commonly reported adverse events were nasopharyngitis (13.5%), schizophrenia (9.0%), insomnia (6.5%), headache (5.5%), and akathisia (5.5%). The discontinuation rate was 4.9% for patients who were switched from aripiprazole as the primary antipsychotic and 25.4% for those who were switched from other antipsychotics. Owing to the serious adverse events that led to treatment discontinuation, careful switching to brexpiprazole is necessary in patients who previously used olanzapine as their primary antipsychotic.https://doi.org/10.1002/npr2.12107antipsychoticsbrexpiprazoledopamine partial agonistschizophreniaswitching |
| spellingShingle | Jun Ishigooka Tomohiro Usami Shuichi Iwashita Yoshitsugu Kojima Satoshi Matsuo Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication) Neuropsychopharmacology Reports antipsychotics brexpiprazole dopamine partial agonist schizophrenia switching |
| title | Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication) |
| title_full | Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication) |
| title_fullStr | Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication) |
| title_full_unstemmed | Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication) |
| title_short | Post‐hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long‐term study (Secondary Publication) |
| title_sort | post hoc analysis investigating the safety and efficacy of brexpiprazole in japanese patients with schizophrenia who were switched from other antipsychotics in a long term study secondary publication |
| topic | antipsychotics brexpiprazole dopamine partial agonist schizophrenia switching |
| url | https://doi.org/10.1002/npr2.12107 |
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