Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants
Aims The aim of this study was the analysis of the risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on the proximal aorta due to aortic disease.Methods and results Data from the department’s register of cardiac surgery was analysed retrospectivel...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-12-01
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| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/7/2/e001278.full |
| _version_ | 1818379848442183680 |
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| author | Bjørn Bendz Johannes Lagethon Bjørnstad Adil Mahboob Khan Henriette Røed-Undlien Ståle Nygård Tom Nilsen Hoel Per Snorre Lingaas |
| author_facet | Bjørn Bendz Johannes Lagethon Bjørnstad Adil Mahboob Khan Henriette Røed-Undlien Ståle Nygård Tom Nilsen Hoel Per Snorre Lingaas |
| author_sort | Bjørn Bendz |
| collection | DOAJ |
| description | Aims The aim of this study was the analysis of the risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on the proximal aorta due to aortic disease.Methods and results Data from the department’s register of cardiac surgery was analysed retrospectively with emphasis on operative mortality. 135 non-elective operations for proximal aortic disease (October 2016 to 2018) were identified, of which 19 died during the first 90 days. DOAC use was the top-ranked risk factor in the univariate analysis with a HR of 9.6 (3.1 to 29), p=0.00007. Using a Cox proportional hazards model including the most relevant risk factors, the risk associated with DOAC use remained significant with a HR of 6.1 (1.4 to 26.3), p=0.015. We did not find increased risk associated with warfarin use.Conclusion In patients undergoing non-elective operations on the proximal aorta due to aortic disease, the use of DOAC is associated with increased operative mortality. |
| first_indexed | 2024-12-14T02:09:18Z |
| format | Article |
| id | doaj.art-742382636acb459a9376975094b4bac1 |
| institution | Directory Open Access Journal |
| issn | 2053-3624 |
| language | English |
| last_indexed | 2024-12-14T02:09:18Z |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj.art-742382636acb459a9376975094b4bac12022-12-21T23:20:48ZengBMJ Publishing GroupOpen Heart2053-36242020-12-017210.1136/openhrt-2020-001278Operative survival in patients with acute aortic disease in the era of newer oral anticoagulantsBjørn Bendz0Johannes Lagethon Bjørnstad1Adil Mahboob Khan2Henriette Røed-Undlien3Ståle Nygård4Tom Nilsen Hoel5Per Snorre Lingaas6Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Cardiothoracic Surgery, Oslo University Hospital, Oslo, NorwayDepartment of Cardiothoracic Surgery, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, NorwayDepartment of Cardiothoracic Surgery, Oslo University Hospital, Oslo, NorwayDepartment of Cardiothoracic Surgery, Oslo University Hospital, Oslo, NorwayAims The aim of this study was the analysis of the risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on the proximal aorta due to aortic disease.Methods and results Data from the department’s register of cardiac surgery was analysed retrospectively with emphasis on operative mortality. 135 non-elective operations for proximal aortic disease (October 2016 to 2018) were identified, of which 19 died during the first 90 days. DOAC use was the top-ranked risk factor in the univariate analysis with a HR of 9.6 (3.1 to 29), p=0.00007. Using a Cox proportional hazards model including the most relevant risk factors, the risk associated with DOAC use remained significant with a HR of 6.1 (1.4 to 26.3), p=0.015. We did not find increased risk associated with warfarin use.Conclusion In patients undergoing non-elective operations on the proximal aorta due to aortic disease, the use of DOAC is associated with increased operative mortality.https://openheart.bmj.com/content/7/2/e001278.full |
| spellingShingle | Bjørn Bendz Johannes Lagethon Bjørnstad Adil Mahboob Khan Henriette Røed-Undlien Ståle Nygård Tom Nilsen Hoel Per Snorre Lingaas Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants Open Heart |
| title | Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants |
| title_full | Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants |
| title_fullStr | Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants |
| title_full_unstemmed | Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants |
| title_short | Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants |
| title_sort | operative survival in patients with acute aortic disease in the era of newer oral anticoagulants |
| url | https://openheart.bmj.com/content/7/2/e001278.full |
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