Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

<p>Abstract</p> <p>Background</p> <p>Inhibitors of the kinase mTOR, such as rapamycin and everolimus, have been used as cancer therapeutics with limited success since some tumours are resistant. Efforts to establish predictive markers to allow selection of patients with...

Full description

Bibliographic Details
Main Authors: Bartlett John MS, Macaskill E Jane, Sabine Vicky S, Suleman Charlotte AB, Hanby Andrew M, Madhok Brijesh, Ingram Nicola, Coleman Louise J, Cookson Victoria J, Satheesha Sampoorna, Dixon J Michael, McElwaine Jim N, Hughes Thomas A
Format: Article
Language:English
Published: BMC 2011-02-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/10/1/19

Similar Items

Similar Items