Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection?
Background. In the follow up of chronic hepatitis B infection (HBV), a significant correlation between quantitative HBsAg titer measurement and HBV DNA level, and moreover with intrahepatic covalently closed circular DNA was already shown. However, besides their impact on long-term follow up, they a...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-05-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119309263 |
| _version_ | 1831759638146580480 |
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| author | Akif Altinbas Bora Aktaş Ömer Basar Osman Yüksel Fuat Ekiz Bariş Yilmaz Sahin Coban |
| author_facet | Akif Altinbas Bora Aktaş Ömer Basar Osman Yüksel Fuat Ekiz Bariş Yilmaz Sahin Coban |
| author_sort | Akif Altinbas |
| collection | DOAJ |
| description | Background. In the follow up of chronic hepatitis B infection (HBV), a significant correlation between quantitative HBsAg titer measurement and HBV DNA level, and moreover with intrahepatic covalently closed circular DNA was already shown. However, besides their impact on long-term follow up, they are really expensive methods, and not available widespread. We aimed to investigate the utility of qualitative measurement of HBsAg titer in prediction of virologic response at the end of the first year of anti-viral treatment in chronic HBV infection.Material and methods. A total of 70 patients receiving anti-viral therapies for chronic HBV infection were included into the study. The patients were evaluated according to Hbe Ag status and response to treatment. The determinations used in the study (biochemical, virologic responses, primary non-response) were accepted as it was described in AASLD.Results. Qualitative HBsAg titer increased significantly in both HBeAg positive and negative patients (p values 0.002 and < 0.000). Increasing of HBsAg titer in first three months is more dramatic in responder group, however the difference was disappeared at the sixth and twelve moths on follow up. Similarly, a fast increasing in anti-HBe titer in HBeAg negative chronic HBV patients was related with higher response at the end of first year therapy. However, the changings at the 12th month of anti-viral treatment were similar in both responder and non-responder groups.Conclusion. In conclusion, the fast increase in qualitative measurement of HBsAg titer seemed to be a predictor of higher anti-viral medication success in chronic HBV patients. However, this meaningful increasing was disappeared on the follow up, particularly after the six months examination. |
| first_indexed | 2024-12-22T01:10:54Z |
| format | Article |
| id | doaj.art-7424feb4c9424cb8ab3b9a3697a83529 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-22T01:10:54Z |
| publishDate | 2012-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-7424feb4c9424cb8ab3b9a3697a835292022-12-21T18:43:58ZengElsevierAnnals of Hepatology1665-26812012-05-01113320325Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection?Akif Altinbas0Bora Aktaş1Ömer Basar2Osman Yüksel3Fuat Ekiz4Bariş Yilmaz5Sahin Coban6Diskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, Turkey; Correspondence and reprint request:Diskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, TurkeyDiskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, TurkeyDiskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, TurkeyDiskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, TurkeyDiskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, TurkeyDiskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology Clinic, Ankara, TurkeyBackground. In the follow up of chronic hepatitis B infection (HBV), a significant correlation between quantitative HBsAg titer measurement and HBV DNA level, and moreover with intrahepatic covalently closed circular DNA was already shown. However, besides their impact on long-term follow up, they are really expensive methods, and not available widespread. We aimed to investigate the utility of qualitative measurement of HBsAg titer in prediction of virologic response at the end of the first year of anti-viral treatment in chronic HBV infection.Material and methods. A total of 70 patients receiving anti-viral therapies for chronic HBV infection were included into the study. The patients were evaluated according to Hbe Ag status and response to treatment. The determinations used in the study (biochemical, virologic responses, primary non-response) were accepted as it was described in AASLD.Results. Qualitative HBsAg titer increased significantly in both HBeAg positive and negative patients (p values 0.002 and < 0.000). Increasing of HBsAg titer in first three months is more dramatic in responder group, however the difference was disappeared at the sixth and twelve moths on follow up. Similarly, a fast increasing in anti-HBe titer in HBeAg negative chronic HBV patients was related with higher response at the end of first year therapy. However, the changings at the 12th month of anti-viral treatment were similar in both responder and non-responder groups.Conclusion. In conclusion, the fast increase in qualitative measurement of HBsAg titer seemed to be a predictor of higher anti-viral medication success in chronic HBV patients. However, this meaningful increasing was disappeared on the follow up, particularly after the six months examination.http://www.sciencedirect.com/science/article/pii/S1665268119309263Chronic HBV infectionQualitative HBsAg titerAnti-viral medication |
| spellingShingle | Akif Altinbas Bora Aktaş Ömer Basar Osman Yüksel Fuat Ekiz Bariş Yilmaz Sahin Coban Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection? Annals of Hepatology Chronic HBV infection Qualitative HBsAg titer Anti-viral medication |
| title | Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection? |
| title_full | Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection? |
| title_fullStr | Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection? |
| title_full_unstemmed | Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection? |
| title_short | Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection? |
| title_sort | is there an association between the measurement of qualitative hbsag and virologic response in chronic hbv infection |
| topic | Chronic HBV infection Qualitative HBsAg titer Anti-viral medication |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119309263 |
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