IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM
Titanium (Ti) is a non-essential metal element. TiO2 is used predominantly in the form of micro and nanoparticles in consumer products, including cosmetics and food. Because of its excellent biocompatibility, the trade-pure titan and its alloys are widely used as an alternative to certain metals in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Peytchinski Publishing
2017-05-01
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| Series: | Journal of IMAB |
| Subjects: | |
| Online Access: | https://www.journal-imab-bg.org/issues-2017/issue2/JofIMAB-2017-23-2p1550-1559.pdf |
| _version_ | 1811207748740710400 |
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| author | Maya Lyapina Mariana Cekova Mariela Deliverska Jordan Galabov Angelina Kisselova |
| author_facet | Maya Lyapina Mariana Cekova Mariela Deliverska Jordan Galabov Angelina Kisselova |
| author_sort | Maya Lyapina |
| collection | DOAJ |
| description | Titanium (Ti) is a non-essential metal element. TiO2 is used predominantly in the form of micro and nanoparticles in consumer products, including cosmetics and food. Because of its excellent biocompatibility, the trade-pure titan and its alloys are widely used as an alternative to certain metals in invasive medicine, surgery, dental medicine. Contemporary data concerning the sources of exposure to titanium, immune reactions to Ti alloys, current knowledge and perspectives of diagnosis of sensitization or allergic reactions to titanium are discussed.
Conclusion: TiO2 is much more stable than pure Ti and alloys used in the implants, that should be taken into account when conducting research and analysing the results. The evidence of possible toxic effects is insufficient. It is difficult to assess the frequency of Ti allergy due to the uncertainty of diagnostic methods, but it is believed that it is very low. This is supported by the evidence that Ti and TiO2 (often as NP) doesn’t penetrate through the healthy skin. Skin patch testing with currently available formulations of Ti and TiO2 has no significant value in clinical practice, and currently, it is assumed that there is no reliable method for diagnosis Ti allergy. The functional analysis of cytokine release and investigation of genetic characteristics could be useful for individual risk assessment in dental implantology. Such studies may also help to investigate separately early and late implant loss, as well as to develop new diagnostic tools. |
| first_indexed | 2024-04-12T04:09:45Z |
| format | Article |
| id | doaj.art-74252cd985a6403e9bf1e92b748aeb60 |
| institution | Directory Open Access Journal |
| issn | 1312-773X |
| language | English |
| last_indexed | 2024-04-12T04:09:45Z |
| publishDate | 2017-05-01 |
| publisher | Peytchinski Publishing |
| record_format | Article |
| series | Journal of IMAB |
| spelling | doaj.art-74252cd985a6403e9bf1e92b748aeb602022-12-22T03:48:32ZengPeytchinski PublishingJournal of IMAB1312-773X2017-05-012321550155910.5272/jimab.2017232.1550IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUMMaya Lyapina0Mariana Cekova1Mariela Deliverska2Jordan Galabov3Angelina Kisselova4Department Hygiene, Medical Ecology and Nutrition, Medical Faculty, Medical University - Sofia, BulgariaDepartment Oral and Image Diagnostic, Faculty of Dental Medicine, Medical University - Sofia, BulgariaDepartment Medical Ethics and Law, Faculty of Public Health, Medical University - Sofia, Bulgaria.Department Oral and Image Diagnostic, Faculty of Dental Medicine, Medical University - Sofia, BulgariaDepartment Oral and Image Diagnostic, Faculty of Dental Medicine, Medical University - Sofia, BulgariaTitanium (Ti) is a non-essential metal element. TiO2 is used predominantly in the form of micro and nanoparticles in consumer products, including cosmetics and food. Because of its excellent biocompatibility, the trade-pure titan and its alloys are widely used as an alternative to certain metals in invasive medicine, surgery, dental medicine. Contemporary data concerning the sources of exposure to titanium, immune reactions to Ti alloys, current knowledge and perspectives of diagnosis of sensitization or allergic reactions to titanium are discussed. Conclusion: TiO2 is much more stable than pure Ti and alloys used in the implants, that should be taken into account when conducting research and analysing the results. The evidence of possible toxic effects is insufficient. It is difficult to assess the frequency of Ti allergy due to the uncertainty of diagnostic methods, but it is believed that it is very low. This is supported by the evidence that Ti and TiO2 (often as NP) doesn’t penetrate through the healthy skin. Skin patch testing with currently available formulations of Ti and TiO2 has no significant value in clinical practice, and currently, it is assumed that there is no reliable method for diagnosis Ti allergy. The functional analysis of cytokine release and investigation of genetic characteristics could be useful for individual risk assessment in dental implantology. Such studies may also help to investigate separately early and late implant loss, as well as to develop new diagnostic tools.https://www.journal-imab-bg.org/issues-2017/issue2/JofIMAB-2017-23-2p1550-1559.pdftitaniumdental implantsbiocompatibilityallergic responsecytokines |
| spellingShingle | Maya Lyapina Mariana Cekova Mariela Deliverska Jordan Galabov Angelina Kisselova IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM Journal of IMAB titanium dental implants biocompatibility allergic response cytokines |
| title | IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM |
| title_full | IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM |
| title_fullStr | IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM |
| title_full_unstemmed | IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM |
| title_short | IMMUNOTOXICOLOGICAL ASPECTS OF BIOCOMPATIBILITY OF TITANIUM |
| title_sort | immunotoxicological aspects of biocompatibility of titanium |
| topic | titanium dental implants biocompatibility allergic response cytokines |
| url | https://www.journal-imab-bg.org/issues-2017/issue2/JofIMAB-2017-23-2p1550-1559.pdf |
| work_keys_str_mv | AT mayalyapina immunotoxicologicalaspectsofbiocompatibilityoftitanium AT marianacekova immunotoxicologicalaspectsofbiocompatibilityoftitanium AT marieladeliverska immunotoxicologicalaspectsofbiocompatibilityoftitanium AT jordangalabov immunotoxicologicalaspectsofbiocompatibilityoftitanium AT angelinakisselova immunotoxicologicalaspectsofbiocompatibilityoftitanium |