Ferritin in pediatric critical illness: a scoping review
This scoping review aimed to elucidate and summarize the predictive role of serum ferritin in critical pediatric illness. The Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology was employed to conduct a scoping review of 5 databases (MEDLINE, CENTRAL, ProQuest, ScienceDir...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2023-03-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2022-00654.pdf |
| _version_ | 1827998427062992896 |
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| author | Ivy Cerelia Valerie Anak Agung Sagung Mirah Prabandari Dyah Kanya Wati |
| author_facet | Ivy Cerelia Valerie Anak Agung Sagung Mirah Prabandari Dyah Kanya Wati |
| author_sort | Ivy Cerelia Valerie |
| collection | DOAJ |
| description | This scoping review aimed to elucidate and summarize the predictive role of serum ferritin in critical pediatric illness. The Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology was employed to conduct a scoping review of 5 databases (MEDLINE, CENTRAL, ProQuest, ScienceDirect, and Epistemonikos) from the date of inception through January 24, 2022. Primary research studies involving subjects aged <18 years and serum ferritin levels were screened and reviewed independently following an a priori defined protocol. Of the 1,580 retrieved studies, 66 were analyzed. Summary statistics of serum ferritin levels for overall and condition-specific studies were reported in 30 (45.4%) and 47 studies (71.2%), respectively. The normal range was defined in 16 studies (24.2%), whereas the threshold was determined in 43 studies (65.1%). A value of <500 ng/mL was most often the upper limit of the normal range. Serum ferritin as a numerical variable (78.9%) was usually significantly higher (80.8%) in the predicted condition than in controls, while as a categorical variable with preset thresholds, ferritin was a significant predictor in 84.6% of studies. A total of 22 predictive thresholds predicted mortality (12 of 46 [26.1%]), morbidity (18 of 46 [39.1%]), and specific (16 of 46 [34.8%]) outcomes in 15 unique conditions. Increased precision in serum ferritin measures followed by close attention to the threshold modeling strategy and reporting can accelerate the translation from evidence to clinical practice. |
| first_indexed | 2024-04-10T05:43:12Z |
| format | Article |
| id | doaj.art-742620c0d2b24cf3a2a488087672e2d3 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-04-10T05:43:12Z |
| publishDate | 2023-03-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-742620c0d2b24cf3a2a488087672e2d32023-03-06T05:24:26ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482023-03-016639810910.3345/cep.2022.0065420125555553Ferritin in pediatric critical illness: a scoping reviewIvy Cerelia Valerie0Anak Agung Sagung Mirah Prabandari1Dyah Kanya Wati2 Department of Child Health, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Bali, Indonesia Mangusada General Hospital, Bali, Indonesia Department of Child Health, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Bali, IndonesiaThis scoping review aimed to elucidate and summarize the predictive role of serum ferritin in critical pediatric illness. The Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology was employed to conduct a scoping review of 5 databases (MEDLINE, CENTRAL, ProQuest, ScienceDirect, and Epistemonikos) from the date of inception through January 24, 2022. Primary research studies involving subjects aged <18 years and serum ferritin levels were screened and reviewed independently following an a priori defined protocol. Of the 1,580 retrieved studies, 66 were analyzed. Summary statistics of serum ferritin levels for overall and condition-specific studies were reported in 30 (45.4%) and 47 studies (71.2%), respectively. The normal range was defined in 16 studies (24.2%), whereas the threshold was determined in 43 studies (65.1%). A value of <500 ng/mL was most often the upper limit of the normal range. Serum ferritin as a numerical variable (78.9%) was usually significantly higher (80.8%) in the predicted condition than in controls, while as a categorical variable with preset thresholds, ferritin was a significant predictor in 84.6% of studies. A total of 22 predictive thresholds predicted mortality (12 of 46 [26.1%]), morbidity (18 of 46 [39.1%]), and specific (16 of 46 [34.8%]) outcomes in 15 unique conditions. Increased precision in serum ferritin measures followed by close attention to the threshold modeling strategy and reporting can accelerate the translation from evidence to clinical practice.http://www.e-cep.org/upload/pdf/cep-2022-00654.pdfferritinspediatric intensive care unitcritical illnessclinical laboratory techniqueshyperferritinemia |
| spellingShingle | Ivy Cerelia Valerie Anak Agung Sagung Mirah Prabandari Dyah Kanya Wati Ferritin in pediatric critical illness: a scoping review Clinical and Experimental Pediatrics ferritins pediatric intensive care unit critical illness clinical laboratory techniques hyperferritinemia |
| title | Ferritin in pediatric critical illness: a scoping review |
| title_full | Ferritin in pediatric critical illness: a scoping review |
| title_fullStr | Ferritin in pediatric critical illness: a scoping review |
| title_full_unstemmed | Ferritin in pediatric critical illness: a scoping review |
| title_short | Ferritin in pediatric critical illness: a scoping review |
| title_sort | ferritin in pediatric critical illness a scoping review |
| topic | ferritins pediatric intensive care unit critical illness clinical laboratory techniques hyperferritinemia |
| url | http://www.e-cep.org/upload/pdf/cep-2022-00654.pdf |
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