Early handling and repeated cross-fostering have opposite effect on mouse emotionality.
Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rode...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00093/full |
| _version_ | 1818066444399673344 |
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| author | Alessandra eLuchetti Alessandra eLuchetti Diego eOddi Valentina eLampis Eleonora eCentofante Armando eFelsani Armando eFelsani Marco eBattaglia Francesca R D'Amato Francesca R D'Amato |
| author_facet | Alessandra eLuchetti Alessandra eLuchetti Diego eOddi Valentina eLampis Eleonora eCentofante Armando eFelsani Armando eFelsani Marco eBattaglia Francesca R D'Amato Francesca R D'Amato |
| author_sort | Alessandra eLuchetti |
| collection | DOAJ |
| description | Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore molecular mechanisms responsible for the observed short and long lasting neurobiological effects of such manipulations. The main aim of this study was to compare the behavioral and hormonal phenotype of young and adult animals exposed to different postnatal treatments. Outbred mice were exposed to i) the classical Handling protocol (H: 15 min-day of separation from the mother from day 1 to 14 of life) or to ii) a Repeated Cross-Fostering protocol (RCF: adoption of litters from day 1 to 4 of life by different dams). Handled mice received more maternal care in infancy and showed the already described reduced emotionality at adulthood. Repeated cross fostered animals did not differ for maternal care received, but showed enhanced sensitivity to separation from the mother in infancy and altered respiratory response to 6%CO2 in breathing air in comparison with controls. Abnormal respiratory responses to hypercapnia are commonly found among humans with panic disorders, and point to RCF-induced instability of the early environment as a valid developmental model for panic disorder. The comparisons between short- and long-term effects of postnatal handling vs. RCF indicate that different types of early adversities are associated with different behavioral profiles, and evoke psychopathologies that can be distinguished according to the neurobiological systems disrupted by early-life manipulations. |
| first_indexed | 2024-12-10T15:07:53Z |
| format | Article |
| id | doaj.art-742624cc48504ebd8580bb5371fb271c |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T15:07:53Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-742624cc48504ebd8580bb5371fb271c2022-12-22T01:44:01ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532015-04-01910.3389/fnbeh.2015.00093129387Early handling and repeated cross-fostering have opposite effect on mouse emotionality.Alessandra eLuchetti0Alessandra eLuchetti1Diego eOddi2Valentina eLampis3Eleonora eCentofante4Armando eFelsani5Armando eFelsani6Marco eBattaglia7Francesca R D'Amato8Francesca R D'Amato9Consiglio Nazionale delle RicercheSapienza UniversityConsiglio Nazionale delle RicercheVita-Salute San Raffaele UniversityConsiglio Nazionale delle RicercheConsiglio Nazionale delle RicercheGenomnia srlLaval UniversityConsiglio Nazionale delle RicercheLaval UniversityEarly life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore molecular mechanisms responsible for the observed short and long lasting neurobiological effects of such manipulations. The main aim of this study was to compare the behavioral and hormonal phenotype of young and adult animals exposed to different postnatal treatments. Outbred mice were exposed to i) the classical Handling protocol (H: 15 min-day of separation from the mother from day 1 to 14 of life) or to ii) a Repeated Cross-Fostering protocol (RCF: adoption of litters from day 1 to 4 of life by different dams). Handled mice received more maternal care in infancy and showed the already described reduced emotionality at adulthood. Repeated cross fostered animals did not differ for maternal care received, but showed enhanced sensitivity to separation from the mother in infancy and altered respiratory response to 6%CO2 in breathing air in comparison with controls. Abnormal respiratory responses to hypercapnia are commonly found among humans with panic disorders, and point to RCF-induced instability of the early environment as a valid developmental model for panic disorder. The comparisons between short- and long-term effects of postnatal handling vs. RCF indicate that different types of early adversities are associated with different behavioral profiles, and evoke psychopathologies that can be distinguished according to the neurobiological systems disrupted by early-life manipulations.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00093/fullMaternal BehaviorPanic DisorderHPA axisoutbred micerespiratory response to hypercapniaattachment behavior. |
| spellingShingle | Alessandra eLuchetti Alessandra eLuchetti Diego eOddi Valentina eLampis Eleonora eCentofante Armando eFelsani Armando eFelsani Marco eBattaglia Francesca R D'Amato Francesca R D'Amato Early handling and repeated cross-fostering have opposite effect on mouse emotionality. Frontiers in Behavioral Neuroscience Maternal Behavior Panic Disorder HPA axis outbred mice respiratory response to hypercapnia attachment behavior. |
| title | Early handling and repeated cross-fostering have opposite effect on mouse emotionality. |
| title_full | Early handling and repeated cross-fostering have opposite effect on mouse emotionality. |
| title_fullStr | Early handling and repeated cross-fostering have opposite effect on mouse emotionality. |
| title_full_unstemmed | Early handling and repeated cross-fostering have opposite effect on mouse emotionality. |
| title_short | Early handling and repeated cross-fostering have opposite effect on mouse emotionality. |
| title_sort | early handling and repeated cross fostering have opposite effect on mouse emotionality |
| topic | Maternal Behavior Panic Disorder HPA axis outbred mice respiratory response to hypercapnia attachment behavior. |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00093/full |
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