Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage

Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage

ABSTRACT Host persistence of bacteria is facilitated by mutational and recombinatorial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated during persistent asymptomatic carriage of Neisseria meningiti...

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Bibliographic Details
Main Authors: Luke R. Green, Ali A. Al-Rubaiawi, Mohammad A. R. M. Al-Maeni, Odile B. Harrison, Matthew Blades, Neil J. Oldfield, David P. J. Turner, Martin C. J. Maiden, Christopher D. Bayliss
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
Neisseria meningitidis
horizontal gene transfer
localized hypermutation
meningitis
meningococcus
phase variation
Online Access:https://journals.asm.org/doi/10.1128/mBio.03068-19

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