Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina
Summary: Neurons form stereotyped microcircuits that underlie specific functions. In the vertebrate retina, the primary rod and cone pathways that convey dim and bright light signals, respectively, exhibit distinct wiring patterns. Rod and cone pathways are thought to be assembled separately during...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222013049 |
| _version_ | 1811274638566621184 |
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| author | Chi Zhang Ayana Hellevik Shunsuke Takeuchi Rachel O. Wong |
| author_facet | Chi Zhang Ayana Hellevik Shunsuke Takeuchi Rachel O. Wong |
| author_sort | Chi Zhang |
| collection | DOAJ |
| description | Summary: Neurons form stereotyped microcircuits that underlie specific functions. In the vertebrate retina, the primary rod and cone pathways that convey dim and bright light signals, respectively, exhibit distinct wiring patterns. Rod and cone pathways are thought to be assembled separately during development. However, using correlative fluorescence imaging and serial electron microscopy, we show here that cross-pathway interactions are involved to achieve pathway-specific connectivity within the inner retina. We found that A17 amacrine cells, a rod pathway-specific cellular component, heavily bias their synaptogenesis with rod bipolar cells (RBCs) but increase their connectivity with cone bipolar cells (CBCs) when RBCs are largely ablated. This cross-pathway synaptic plasticity occurs during synaptogenesis and is triggered even on partial loss of RBCs. Thus, A17 cells adopt a hierarchical approach in selecting postsynaptic partners from functionally distinct pathways (RBC>CBC), in which contact and/or synaptogenesis with preferred partners (RBCs) influences connectivity with less-preferred partners (CBCs). |
| first_indexed | 2024-04-12T23:22:48Z |
| format | Article |
| id | doaj.art-7427e952087e4b70802b4abccaafb73d |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T23:22:48Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-7427e952087e4b70802b4abccaafb73d2022-12-22T03:12:29ZengElsevieriScience2589-00422022-09-01259105032Hierarchical partner selection shapes rod-cone pathway specificity in the inner retinaChi Zhang0Ayana Hellevik1Shunsuke Takeuchi2Rachel O. Wong3Department of Biological Structure, University of Washington, Seattle, WA 98195, USADepartment of Biological Structure, University of Washington, Seattle, WA 98195, USADepartment of Biological Sciences, University of Tokyo, Tokyo 113-0033, JapanDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA; Corresponding authorSummary: Neurons form stereotyped microcircuits that underlie specific functions. In the vertebrate retina, the primary rod and cone pathways that convey dim and bright light signals, respectively, exhibit distinct wiring patterns. Rod and cone pathways are thought to be assembled separately during development. However, using correlative fluorescence imaging and serial electron microscopy, we show here that cross-pathway interactions are involved to achieve pathway-specific connectivity within the inner retina. We found that A17 amacrine cells, a rod pathway-specific cellular component, heavily bias their synaptogenesis with rod bipolar cells (RBCs) but increase their connectivity with cone bipolar cells (CBCs) when RBCs are largely ablated. This cross-pathway synaptic plasticity occurs during synaptogenesis and is triggered even on partial loss of RBCs. Thus, A17 cells adopt a hierarchical approach in selecting postsynaptic partners from functionally distinct pathways (RBC>CBC), in which contact and/or synaptogenesis with preferred partners (RBCs) influences connectivity with less-preferred partners (CBCs).http://www.sciencedirect.com/science/article/pii/S2589004222013049Sensory neurosciencecell biologyexperimental systems for structural biology |
| spellingShingle | Chi Zhang Ayana Hellevik Shunsuke Takeuchi Rachel O. Wong Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina iScience Sensory neuroscience cell biology experimental systems for structural biology |
| title | Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina |
| title_full | Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina |
| title_fullStr | Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina |
| title_full_unstemmed | Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina |
| title_short | Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina |
| title_sort | hierarchical partner selection shapes rod cone pathway specificity in the inner retina |
| topic | Sensory neuroscience cell biology experimental systems for structural biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222013049 |
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