Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data
The data here consists of calcium imaging of human neuroblastoma SH-SY5Y cells treated with the calcium-sensitive dye Fluo-4AM and then incubated with nanomolar concentrations of either human or rat Alzheimer’s β-amyloid peptide Aβ1-42. These data are both of a qualitative (fluorescence micrographs)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916000251 |
| _version_ | 1818029802231169024 |
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| author | Coralie Di Scala Nouara Yahi Alessandra Flores Sonia Boutemeur Nazim Kourdougli Henri Chahinian Jacques Fantini |
| author_facet | Coralie Di Scala Nouara Yahi Alessandra Flores Sonia Boutemeur Nazim Kourdougli Henri Chahinian Jacques Fantini |
| author_sort | Coralie Di Scala |
| collection | DOAJ |
| description | The data here consists of calcium imaging of human neuroblastoma SH-SY5Y cells treated with the calcium-sensitive dye Fluo-4AM and then incubated with nanomolar concentrations of either human or rat Alzheimer’s β-amyloid peptide Aβ1-42. These data are both of a qualitative (fluorescence micrographs) and semi-quantitative nature (estimation of intracellular calcium concentrations of cells probed by Aβ1-42 peptides vs. control untreated cells). Since rat Aβ1-42 differs from its human counterpart at only three amino acid positions, this comparative study is a good assessment of the specificity of the amyloid pore forming assay. The interpretation of this dataset is presented in the accompanying study “Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides” [1]. |
| first_indexed | 2024-12-10T05:25:28Z |
| format | Article |
| id | doaj.art-74287fc641f147e699aa1f678b00e99d |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-10T05:25:28Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-74287fc641f147e699aa1f678b00e99d2022-12-22T02:00:42ZengElsevierData in Brief2352-34092016-03-016640643Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging dataCoralie Di Scala0Nouara Yahi1Alessandra Flores2Sonia Boutemeur3Nazim Kourdougli4Henri Chahinian5Jacques Fantini6Aix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, FranceAix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, FranceAix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, FranceAix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, FranceINSERM, INMED, Parc Scientifique de Luminy, 13009 Marseille, FranceAix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, FranceAix-Marseille Université, PPSN-EA4674, Faculté des Sciences, Marseille, France; Corresponding author.The data here consists of calcium imaging of human neuroblastoma SH-SY5Y cells treated with the calcium-sensitive dye Fluo-4AM and then incubated with nanomolar concentrations of either human or rat Alzheimer’s β-amyloid peptide Aβ1-42. These data are both of a qualitative (fluorescence micrographs) and semi-quantitative nature (estimation of intracellular calcium concentrations of cells probed by Aβ1-42 peptides vs. control untreated cells). Since rat Aβ1-42 differs from its human counterpart at only three amino acid positions, this comparative study is a good assessment of the specificity of the amyloid pore forming assay. The interpretation of this dataset is presented in the accompanying study “Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides” [1].http://www.sciencedirect.com/science/article/pii/S2352340916000251 |
| spellingShingle | Coralie Di Scala Nouara Yahi Alessandra Flores Sonia Boutemeur Nazim Kourdougli Henri Chahinian Jacques Fantini Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data Data in Brief |
| title | Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data |
| title_full | Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data |
| title_fullStr | Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data |
| title_full_unstemmed | Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data |
| title_short | Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data |
| title_sort | comparison of the amyloid pore forming properties of rat and human alzheimer s beta amyloid peptide 1 42 calcium imaging data |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916000251 |
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