Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people
BackgroundChinese visceral adiposity index (CVAI) is a reliable indicator of visceral obesity, but little is known about the association of CVAI with comorbidity of hypertension (HTN) and diabetes mellitus (DM). This study aimed to explore the associations of CVAI with HTN-DM comorbidity, HTN or DM,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187381/full |
| _version_ | 1827949662125948928 |
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| author | Yongcheng Ren Yongcheng Ren Yongcheng Ren Lulu Cheng Ranran Qie Minghui Han Lingzhen Kong Wei Yan Zheng Li Yiduo Li Yicun Lei |
| author_facet | Yongcheng Ren Yongcheng Ren Yongcheng Ren Lulu Cheng Ranran Qie Minghui Han Lingzhen Kong Wei Yan Zheng Li Yiduo Li Yicun Lei |
| author_sort | Yongcheng Ren |
| collection | DOAJ |
| description | BackgroundChinese visceral adiposity index (CVAI) is a reliable indicator of visceral obesity, but little is known about the association of CVAI with comorbidity of hypertension (HTN) and diabetes mellitus (DM). This study aimed to explore the associations of CVAI with HTN-DM comorbidity, HTN or DM, HTN, and DM in elderly people and evaluate the mediating role of insulin resistance in the associations.MethodsA total of 3,316 Chinese participants aged ≥60 years were included in this cross-sectional study. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were applied to explore the dose–response associations. Mediation analyses were used to assess the mediating effect of triglyceride-glucose (TyG) index in the associations.ResultsThe prevalence rate of HTN-DM comorbidity, HTN or DM, HTN, and DM was 13.78%, 72.26%, 67.16%, and 18.88%, respectively. Linear associations between CVAI and HTN-DM comorbidity, HTN or DM, HTN, and DM were found, and ORs (95%CIs) were 1.45 (1.30–1.61), 1.39 (1.28–1.52), 1.36 (1.25–1.48), and 1.28 (1.16–1.41) for per SD increase in CVAI. Compared with quartile 1 of CVAI, the risk of HTN-DM comorbidity, HTN or DM, HTN, and DM increased 190%, 125%, 112%, and 96% for quartile 4. In addition, we found TyG index playing a key role in the associations of CVAI with HTN-DM comorbidity, HTN or DM, and DM.ConclusionCVAI is linearly and positively correlated with HTN-DM comorbidity, HTN or DM, HTN, and DM. The potential mechanism is insulin resistance largely mediating the associations. |
| first_indexed | 2024-04-09T13:13:28Z |
| format | Article |
| id | doaj.art-7428e603a5d345df94151d4420322ad2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T13:13:28Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7428e603a5d345df94151d4420322ad22023-05-12T05:47:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11873811187381Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly peopleYongcheng Ren0Yongcheng Ren1Yongcheng Ren2Lulu Cheng3Ranran Qie4Minghui Han5Lingzhen Kong6Wei Yan7Zheng Li8Yiduo Li9Yicun Lei10Institute of Health Data Management, Huanghuai University, Zhumadian, He’nan, ChinaAffiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He’nan, ChinaJiyuan Center for Disease Control and Prevention, Jiyuan, He’nan, ChinaAffiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He’nan, ChinaDepartment of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, ChinaAffiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He’nan, ChinaAffiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He’nan, ChinaInstitute of Health Data Management, Huanghuai University, Zhumadian, He’nan, ChinaInstitute of Health Data Management, Huanghuai University, Zhumadian, He’nan, ChinaInstitute of Health Data Management, Huanghuai University, Zhumadian, He’nan, ChinaBackgroundChinese visceral adiposity index (CVAI) is a reliable indicator of visceral obesity, but little is known about the association of CVAI with comorbidity of hypertension (HTN) and diabetes mellitus (DM). This study aimed to explore the associations of CVAI with HTN-DM comorbidity, HTN or DM, HTN, and DM in elderly people and evaluate the mediating role of insulin resistance in the associations.MethodsA total of 3,316 Chinese participants aged ≥60 years were included in this cross-sectional study. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were applied to explore the dose–response associations. Mediation analyses were used to assess the mediating effect of triglyceride-glucose (TyG) index in the associations.ResultsThe prevalence rate of HTN-DM comorbidity, HTN or DM, HTN, and DM was 13.78%, 72.26%, 67.16%, and 18.88%, respectively. Linear associations between CVAI and HTN-DM comorbidity, HTN or DM, HTN, and DM were found, and ORs (95%CIs) were 1.45 (1.30–1.61), 1.39 (1.28–1.52), 1.36 (1.25–1.48), and 1.28 (1.16–1.41) for per SD increase in CVAI. Compared with quartile 1 of CVAI, the risk of HTN-DM comorbidity, HTN or DM, HTN, and DM increased 190%, 125%, 112%, and 96% for quartile 4. In addition, we found TyG index playing a key role in the associations of CVAI with HTN-DM comorbidity, HTN or DM, and DM.ConclusionCVAI is linearly and positively correlated with HTN-DM comorbidity, HTN or DM, HTN, and DM. The potential mechanism is insulin resistance largely mediating the associations.https://www.frontiersin.org/articles/10.3389/fendo.2023.1187381/fullChinese visceral adiposity indexcomorbiditymediation analysiselder peopleinsulin resistance |
| spellingShingle | Yongcheng Ren Yongcheng Ren Yongcheng Ren Lulu Cheng Ranran Qie Minghui Han Lingzhen Kong Wei Yan Zheng Li Yiduo Li Yicun Lei Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people Frontiers in Endocrinology Chinese visceral adiposity index comorbidity mediation analysis elder people insulin resistance |
| title | Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people |
| title_full | Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people |
| title_fullStr | Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people |
| title_full_unstemmed | Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people |
| title_short | Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people |
| title_sort | dose response association of chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people |
| topic | Chinese visceral adiposity index comorbidity mediation analysis elder people insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187381/full |
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