Angiogenesis in the corpus luteum
<p>Abstract</p> <p>The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-11-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/1/1/88 |
| Summary: | <p>Abstract</p> <p>The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase <it>in vivo </it>by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.</p> |
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| ISSN: | 1477-7827 |