Angiogenesis in the corpus luteum
<p>Abstract</p> <p>The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-11-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/1/1/88 |
| _version_ | 1828296772227694592 |
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| author | Wulff Christine Fraser Hamish M |
| author_facet | Wulff Christine Fraser Hamish M |
| author_sort | Wulff Christine |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase <it>in vivo </it>by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.</p> |
| first_indexed | 2024-04-13T12:17:13Z |
| format | Article |
| id | doaj.art-7429dbd873cf4cb0972f5921fc83cce0 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-13T12:17:13Z |
| publishDate | 2003-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-7429dbd873cf4cb0972f5921fc83cce02022-12-22T02:47:20ZengBMCReproductive Biology and Endocrinology1477-78272003-11-01118810.1186/1477-7827-1-88Angiogenesis in the corpus luteumWulff ChristineFraser Hamish M<p>Abstract</p> <p>The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase <it>in vivo </it>by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.</p>http://www.rbej.com/content/1/1/88 |
| spellingShingle | Wulff Christine Fraser Hamish M Angiogenesis in the corpus luteum Reproductive Biology and Endocrinology |
| title | Angiogenesis in the corpus luteum |
| title_full | Angiogenesis in the corpus luteum |
| title_fullStr | Angiogenesis in the corpus luteum |
| title_full_unstemmed | Angiogenesis in the corpus luteum |
| title_short | Angiogenesis in the corpus luteum |
| title_sort | angiogenesis in the corpus luteum |
| url | http://www.rbej.com/content/1/1/88 |
| work_keys_str_mv | AT wulffchristine angiogenesisinthecorpusluteum AT fraserhamishm angiogenesisinthecorpusluteum |