Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection
Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, h...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322002558 |
| _version_ | 1811295052540936192 |
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| author | Hardeep Singh Tuli Vivek Kumar Garg Sakshi Bhushan Vivek Uttam Uttam Sharma Aklank Jain Katrin Sak Vikas Yadav Jose M. Lorenzo Kuldeep Dhama Tapan Behl Gautam Sethi |
| author_facet | Hardeep Singh Tuli Vivek Kumar Garg Sakshi Bhushan Vivek Uttam Uttam Sharma Aklank Jain Katrin Sak Vikas Yadav Jose M. Lorenzo Kuldeep Dhama Tapan Behl Gautam Sethi |
| author_sort | Hardeep Singh Tuli |
| collection | DOAJ |
| description | Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and pathological processes, including various cancers. In the present review, the structure, chemistry and miR targeting efficacy of quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin against several cancer types are comprehensively discussed. miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future. |
| first_indexed | 2024-04-13T05:26:42Z |
| format | Article |
| id | doaj.art-742afcb4071f4fffaa2a379037ed31dc |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-04-13T05:26:42Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-742afcb4071f4fffaa2a379037ed31dc2022-12-22T03:00:34ZengElsevierTranslational Oncology1936-52332023-01-0127101596Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfectionHardeep Singh Tuli0Vivek Kumar Garg1Sakshi Bhushan2Vivek Uttam3Uttam Sharma4Aklank Jain5Katrin Sak6Vikas Yadav7Jose M. Lorenzo8Kuldeep Dhama9Tapan Behl10Gautam Sethi11Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, IndiaDepartment of Medical Lab Technology, University Institute of Applied Health Sciences, Chandigarh University, Gharuan, Mohali, Punjab, 140413, IndiaDepartment of Botany, Central University Jammu, Jammu and Kashmir 181143, IndiaDepartment of Zoology, Central University of Punjab, Village-Ghudda, Punjab 151401, IndiaDepartment of Zoology, Central University of Punjab, Village-Ghudda, Punjab 151401, IndiaDepartment of Zoology, Central University of Punjab, Village-Ghudda, Punjab 151401, IndiaNGO Praeventio, Tartu 50407, EstoniaDepartment of Translational Medicine, Clinical Research Centre, Skåne University Hospital, Lund University, SE-20213 Malmö, SwedenCentro Tecnológico de la Carne de Galicia, Adva. Galicia n° 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, Ourense 32900, SpainDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh 243122, IndiaDepartment of Pharmacology, School of Health Sciences & Technology (SoHST), University of Petroleum and Energy Studies, Bidholi, Dehradun, Uttarakhand 248007, India; Corresponding authors.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; Corresponding authors.Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and pathological processes, including various cancers. In the present review, the structure, chemistry and miR targeting efficacy of quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin against several cancer types are comprehensively discussed. miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future.http://www.sciencedirect.com/science/article/pii/S1936523322002558MicroRNAsFlavonoidsCancerAnti-proliferationApoptosisSynergism |
| spellingShingle | Hardeep Singh Tuli Vivek Kumar Garg Sakshi Bhushan Vivek Uttam Uttam Sharma Aklank Jain Katrin Sak Vikas Yadav Jose M. Lorenzo Kuldeep Dhama Tapan Behl Gautam Sethi Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection Translational Oncology MicroRNAs Flavonoids Cancer Anti-proliferation Apoptosis Synergism |
| title | Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection |
| title_full | Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection |
| title_fullStr | Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection |
| title_full_unstemmed | Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection |
| title_short | Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection |
| title_sort | natural flavonoids exhibit potent anticancer activity by targeting micrornas in cancer a signature step hinting towards clinical perfection |
| topic | MicroRNAs Flavonoids Cancer Anti-proliferation Apoptosis Synergism |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322002558 |
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