Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

Abstract Background A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is associated with the antidepressant effects of ketamine and the interact...

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Bibliographic Details
Main Authors: Xiao-Hui Tang, Guang-Fen Zhang, Ning Xu, Gui-Fang Duan, Min Jia, Ru Liu, Zhi-Qiang Zhou, Jian-Jun Yang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Ketamine
Antidepressant
Extrasynaptic
CaMKIIα
GluN2B
Online Access:http://link.springer.com/article/10.1186/s12974-020-01843-z

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