Success rates of MRSA decolonization and factors associated with failure
Abstract Background We evaluated the success rate of MRSA decolonization directly after treatment and after one year in patients who were treated at the outpatient MRSA clinic of a large university medical centre to identify potential contributing factors to treatment success and failure. Methods Da...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13756-022-01177-w |
| _version_ | 1828096963634003968 |
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| author | Wing-Kee Yiek Mirjam Tromp Riet Strik-Albers Koen van Aerde Nannet van der Geest-Blankert Heiman F. L. Wertheim Corianne Meijer Alma Tostmann Chantal P. Bleeker-Rovers |
| author_facet | Wing-Kee Yiek Mirjam Tromp Riet Strik-Albers Koen van Aerde Nannet van der Geest-Blankert Heiman F. L. Wertheim Corianne Meijer Alma Tostmann Chantal P. Bleeker-Rovers |
| author_sort | Wing-Kee Yiek |
| collection | DOAJ |
| description | Abstract Background We evaluated the success rate of MRSA decolonization directly after treatment and after one year in patients who were treated at the outpatient MRSA clinic of a large university medical centre to identify potential contributing factors to treatment success and failure. Methods Data from November 1, 2013 to August 1, 2020 were used. Only patients who had undergone complete MRSA decolonization were included. Risk factors for MRSA treatment failure were identified using a multivariable logistic regression model. Results In total, 127 MRSA carriers were included: 7 had uncomplicated carriage, 91 had complicated carriage, and 29 patients had complicated carriage in combination with an infection. In complicated carriers and complicated carriers with an infection final treatment was successful in 75.0%. Risk factors for initial treatment failure included having one or more comorbidities and not testing the household members. Risk factors for final treatment failure were living in a refugee centre, being of younger age (0–17 years), and having one or more comorbidities. Conclusions The results of this study indicate that patients with a refugee status and children treated at the paediatric clinic have a higher risk of MRSA decolonisation treatment failure. For this reason, it might be useful to revise decolonization strategies for these subgroups and to refer these patients to specialized outpatient clinics in order to achieve higher treatment success rates. |
| first_indexed | 2024-04-11T07:39:38Z |
| format | Article |
| id | doaj.art-742fbc40eca0473da77ce1829a2a75d4 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-11T07:39:38Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-742fbc40eca0473da77ce1829a2a75d42022-12-22T04:36:38ZengBMCAntimicrobial Resistance and Infection Control2047-29942022-11-0111111410.1186/s13756-022-01177-wSuccess rates of MRSA decolonization and factors associated with failureWing-Kee Yiek0Mirjam Tromp1Riet Strik-Albers2Koen van Aerde3Nannet van der Geest-Blankert4Heiman F. L. Wertheim5Corianne Meijer6Alma Tostmann7Chantal P. Bleeker-Rovers8Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical CenterDepartment of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical CenterDepartment of Paediatric Infectious Disease and Immunology, Radboud University Medical Center, Radboudumc Institute for Molecular Life Sciences, Radboudumc Amalia Children’s HospitalDepartment of Paediatric Infectious Disease and Immunology, Radboud University Medical Center, Radboudumc Institute for Molecular Life Sciences, Radboudumc Amalia Children’s HospitalDepartment of Occupational Health, Radboud University Medical CenterDepartment of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud University Medical CenterDepartment of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud University Medical CenterDepartment of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud University Medical CenterDepartment of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical CenterAbstract Background We evaluated the success rate of MRSA decolonization directly after treatment and after one year in patients who were treated at the outpatient MRSA clinic of a large university medical centre to identify potential contributing factors to treatment success and failure. Methods Data from November 1, 2013 to August 1, 2020 were used. Only patients who had undergone complete MRSA decolonization were included. Risk factors for MRSA treatment failure were identified using a multivariable logistic regression model. Results In total, 127 MRSA carriers were included: 7 had uncomplicated carriage, 91 had complicated carriage, and 29 patients had complicated carriage in combination with an infection. In complicated carriers and complicated carriers with an infection final treatment was successful in 75.0%. Risk factors for initial treatment failure included having one or more comorbidities and not testing the household members. Risk factors for final treatment failure were living in a refugee centre, being of younger age (0–17 years), and having one or more comorbidities. Conclusions The results of this study indicate that patients with a refugee status and children treated at the paediatric clinic have a higher risk of MRSA decolonisation treatment failure. For this reason, it might be useful to revise decolonization strategies for these subgroups and to refer these patients to specialized outpatient clinics in order to achieve higher treatment success rates.https://doi.org/10.1186/s13756-022-01177-wColonizationDecolonizationMRSATreatment success |
| spellingShingle | Wing-Kee Yiek Mirjam Tromp Riet Strik-Albers Koen van Aerde Nannet van der Geest-Blankert Heiman F. L. Wertheim Corianne Meijer Alma Tostmann Chantal P. Bleeker-Rovers Success rates of MRSA decolonization and factors associated with failure Antimicrobial Resistance and Infection Control Colonization Decolonization MRSA Treatment success |
| title | Success rates of MRSA decolonization and factors associated with failure |
| title_full | Success rates of MRSA decolonization and factors associated with failure |
| title_fullStr | Success rates of MRSA decolonization and factors associated with failure |
| title_full_unstemmed | Success rates of MRSA decolonization and factors associated with failure |
| title_short | Success rates of MRSA decolonization and factors associated with failure |
| title_sort | success rates of mrsa decolonization and factors associated with failure |
| topic | Colonization Decolonization MRSA Treatment success |
| url | https://doi.org/10.1186/s13756-022-01177-w |
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