Primary leiomyosarcoma with osteosarcomatous differentiation of the breast
Primary leiomyosarcoma with osteosarcomatous differentiation of the breast is an uncommon entity. We present the case of a 37-year-old female who presented with a lump in the breast and pulmonary lesions on PET-CT, for which she underwent a toilet mastectomy. Histopathological examination revealed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2024-02-01
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| Series: | Autopsy and Case Reports |
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| Online Access: | https://www.revistas.usp.br/autopsy/article/view/222440 |
| _version_ | 1797294405168660480 |
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| author | Ekta Sethi Sunayana Misra Arvind Ahuja |
| author_facet | Ekta Sethi Sunayana Misra Arvind Ahuja |
| author_sort | Ekta Sethi |
| collection | DOAJ |
| description |
Primary leiomyosarcoma with osteosarcomatous differentiation of the breast is an uncommon entity. We present the case of a 37-year-old female who presented with a lump in the breast and pulmonary lesions on PET-CT, for which she underwent a toilet mastectomy. Histopathological examination revealed a tumor with cells arranged in sheets. These tumor cells had moderate eosinophilic cytoplasm, highly pleomorphic, irregular hyperchromatic nuclei, coarse chromatin, and prominent nucleoli. Areas with spindle-cell morphology were noted. Osteoid was seen intermingling with the tumor along with numerous osteoclast-like multinucleate giant cells. A wide panel of Immunohistochemistry was applied, and Desmin, h-Caldesmon, SMA, and Vimentin were positive. The patient died 3 months post-surgery and had a recurrence at the surgical site.
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| first_indexed | 2024-03-07T21:30:43Z |
| format | Article |
| id | doaj.art-742fda1d37904c809f1e4e1e91bfe3ae |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-03-07T21:30:43Z |
| publishDate | 2024-02-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-742fda1d37904c809f1e4e1e91bfe3ae2024-02-26T16:08:02ZengUniversity of São PauloAutopsy and Case Reports2236-19602024-02-0114Primary leiomyosarcoma with osteosarcomatous differentiation of the breastEkta Sethi0Sunayana Misra1Arvind Ahuja2Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Department of Pathology, New Delhi, IndiaSir Ganga Ram Hospital, Histopathology Department, New Delhi, India Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Department of Pathology, New Delhi, India Primary leiomyosarcoma with osteosarcomatous differentiation of the breast is an uncommon entity. We present the case of a 37-year-old female who presented with a lump in the breast and pulmonary lesions on PET-CT, for which she underwent a toilet mastectomy. Histopathological examination revealed a tumor with cells arranged in sheets. These tumor cells had moderate eosinophilic cytoplasm, highly pleomorphic, irregular hyperchromatic nuclei, coarse chromatin, and prominent nucleoli. Areas with spindle-cell morphology were noted. Osteoid was seen intermingling with the tumor along with numerous osteoclast-like multinucleate giant cells. A wide panel of Immunohistochemistry was applied, and Desmin, h-Caldesmon, SMA, and Vimentin were positive. The patient died 3 months post-surgery and had a recurrence at the surgical site. https://www.revistas.usp.br/autopsy/article/view/222440BreastLeiomyosarcomaMastectomySarcoma |
| spellingShingle | Ekta Sethi Sunayana Misra Arvind Ahuja Primary leiomyosarcoma with osteosarcomatous differentiation of the breast Autopsy and Case Reports Breast Leiomyosarcoma Mastectomy Sarcoma |
| title | Primary leiomyosarcoma with osteosarcomatous differentiation of the breast |
| title_full | Primary leiomyosarcoma with osteosarcomatous differentiation of the breast |
| title_fullStr | Primary leiomyosarcoma with osteosarcomatous differentiation of the breast |
| title_full_unstemmed | Primary leiomyosarcoma with osteosarcomatous differentiation of the breast |
| title_short | Primary leiomyosarcoma with osteosarcomatous differentiation of the breast |
| title_sort | primary leiomyosarcoma with osteosarcomatous differentiation of the breast |
| topic | Breast Leiomyosarcoma Mastectomy Sarcoma |
| url | https://www.revistas.usp.br/autopsy/article/view/222440 |
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