Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging
Retinyl palmitate (RP) is a vitamin A derivative that has been widely used in anti-aging and skin treatment. The aim of this study is to investigate the effect of RP on UVB (Ultraviolet radiation B) induced photoaging and its potential mechanism. Immunofluorescence assay demonstrates that RP can red...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1278838/full |
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| author | Peng Shu Peng Shu Peng Shu Menggeng Li Nan Zhao Yuan Wang Lanyue Zhang Zhiyun Du Zhiyun Du Zhiyun Du |
| author_facet | Peng Shu Peng Shu Peng Shu Menggeng Li Nan Zhao Yuan Wang Lanyue Zhang Zhiyun Du Zhiyun Du Zhiyun Du |
| author_sort | Peng Shu |
| collection | DOAJ |
| description | Retinyl palmitate (RP) is a vitamin A derivative that has been widely used in anti-aging and skin treatment. The aim of this study is to investigate the effect of RP on UVB (Ultraviolet radiation B) induced photoaging and its potential mechanism. Immunofluorescence assay demonstrates that RP can reduce collagen degradation in skin cells by UVB radiation and reduce apoptosis of skin cells. Cell migration assay reveals that RP can increase cell migration rate, helping to repair skin damage and restore cell viability. Immunohistochemical assays indicate that RP can significantly reduce the expression of IL-6, IL-1β, TNF-α induced by UVB radiation. Moreover, metabolomics and transcriptomics results suggest that RP regulates several metabolic pathways and gene expression, particularly in inflammatory signaling pathways, collagen synthesis and apoptosis, exhibiting significant regulatory effects. Furthermore, network pharmacological analysis predicts that RP may affect UVB-induced photoaging by regulating multiple key proteins and signaling pathways. Overall, this study demonstrates that RP has significant anti-photoaging ability, acting through several pathways including inhibition of inflammatory response, promotion of collagen synthesis and inhibition of apoptosis. These results provide a scientific basis for the application of RP in skin anti-photoaging and therapy, enabling the potential usage of RP to skin care products. |
| first_indexed | 2024-03-11T17:10:21Z |
| format | Article |
| id | doaj.art-742fe14f026a428693c1c743b493631e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T17:10:21Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-742fe14f026a428693c1c743b493631e2023-10-20T06:08:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-10-011410.3389/fphar.2023.12788381278838Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoagingPeng Shu0Peng Shu1Peng Shu2Menggeng Li3Nan Zhao4Yuan Wang5Lanyue Zhang6Zhiyun Du7Zhiyun Du8Zhiyun Du9State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xing Jiang, ChinaHBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, Guangdong, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaHBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, Guangdong, ChinaHBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, Guangdong, ChinaHBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, Guangdong, ChinaSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, ChinaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xing Jiang, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, ChinaRetinyl palmitate (RP) is a vitamin A derivative that has been widely used in anti-aging and skin treatment. The aim of this study is to investigate the effect of RP on UVB (Ultraviolet radiation B) induced photoaging and its potential mechanism. Immunofluorescence assay demonstrates that RP can reduce collagen degradation in skin cells by UVB radiation and reduce apoptosis of skin cells. Cell migration assay reveals that RP can increase cell migration rate, helping to repair skin damage and restore cell viability. Immunohistochemical assays indicate that RP can significantly reduce the expression of IL-6, IL-1β, TNF-α induced by UVB radiation. Moreover, metabolomics and transcriptomics results suggest that RP regulates several metabolic pathways and gene expression, particularly in inflammatory signaling pathways, collagen synthesis and apoptosis, exhibiting significant regulatory effects. Furthermore, network pharmacological analysis predicts that RP may affect UVB-induced photoaging by regulating multiple key proteins and signaling pathways. Overall, this study demonstrates that RP has significant anti-photoaging ability, acting through several pathways including inhibition of inflammatory response, promotion of collagen synthesis and inhibition of apoptosis. These results provide a scientific basis for the application of RP in skin anti-photoaging and therapy, enabling the potential usage of RP to skin care products.https://www.frontiersin.org/articles/10.3389/fphar.2023.1278838/fullretinyl palmitateUVB induced photoagingskin healinganti-agingvitamin A derivative |
| spellingShingle | Peng Shu Peng Shu Peng Shu Menggeng Li Nan Zhao Yuan Wang Lanyue Zhang Zhiyun Du Zhiyun Du Zhiyun Du Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging Frontiers in Pharmacology retinyl palmitate UVB induced photoaging skin healing anti-aging vitamin A derivative |
| title | Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging |
| title_full | Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging |
| title_fullStr | Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging |
| title_full_unstemmed | Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging |
| title_short | Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging |
| title_sort | efficacy and mechanism of retinyl palmitate against uvb induced skin photoaging |
| topic | retinyl palmitate UVB induced photoaging skin healing anti-aging vitamin A derivative |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1278838/full |
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