Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions
Abstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and explorator...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300334&lng=en&tlng=en |
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| author | João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira |
| author_facet | João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira |
| author_sort | João Paulo Ramalho Correia |
| collection | DOAJ |
| description | Abstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada. RESULTS: The average age of patients with Chagas disease was 62 years, with the majority residing in the Ceará countryside (86.7%), and having low education levels (63.3% with elementary school education). Regarding family income, most patients belonged to a household that earned ≤1-2 times the minimum wage per month. Approximately 73% of these patients complied with the BNZ treatment, and nearly 7% underwent therapy interruption after medical evaluation. A total of 189 DRPs were identified, of which 51.9% (n=98) were classified as potential, and 48.1% (n=91) as actual. The most frequent DRPs were related to safety (qualitative safety; n=70; 37%), necessity (non-adherence; n=52; 27.5%), and effectiveness (qualitative effectiveness/non-optimal drug selection; n=45; 23.8%). Among the 216 PIs conducted, the majority were related to patient education (n=168; 77.8%) and pharmacological strategy (n=42; 19.4%). CONCLUSIONS: This study indicates the need for pharmacotherapeutic monitoring in patients with Chagas because of the high number of therapeutic interventions, DRPs (approximately 3 DRPs/patient), BNZ adherence, and polypharmacy. |
| first_indexed | 2024-12-12T19:44:12Z |
| format | Article |
| id | doaj.art-743082d0a1974af29e5eb4b5f1f901d5 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T19:44:12Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-743082d0a1974af29e5eb4b5f1f901d52022-12-22T00:14:07ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984950333434010.1590/0037-8682-0474-2016S0037-86822017002300334Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventionsJoão Paulo Ramalho CorreiaAlanna Carla da CostaEduardo Arrais RochaAna Rosa Pinto QuiduteDarlan da Silva CândidoÂngela Maria de Souza PoncianoMarta Maria de França FontelesMaria de Fátima OliveiraAbstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada. RESULTS: The average age of patients with Chagas disease was 62 years, with the majority residing in the Ceará countryside (86.7%), and having low education levels (63.3% with elementary school education). Regarding family income, most patients belonged to a household that earned ≤1-2 times the minimum wage per month. Approximately 73% of these patients complied with the BNZ treatment, and nearly 7% underwent therapy interruption after medical evaluation. A total of 189 DRPs were identified, of which 51.9% (n=98) were classified as potential, and 48.1% (n=91) as actual. The most frequent DRPs were related to safety (qualitative safety; n=70; 37%), necessity (non-adherence; n=52; 27.5%), and effectiveness (qualitative effectiveness/non-optimal drug selection; n=45; 23.8%). Among the 216 PIs conducted, the majority were related to patient education (n=168; 77.8%) and pharmacological strategy (n=42; 19.4%). CONCLUSIONS: This study indicates the need for pharmacotherapeutic monitoring in patients with Chagas because of the high number of therapeutic interventions, DRPs (approximately 3 DRPs/patient), BNZ adherence, and polypharmacy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300334&lng=en&tlng=enChagas diseasePharmaceutical carePharmacotherapy |
| spellingShingle | João Paulo Ramalho Correia Alanna Carla da Costa Eduardo Arrais Rocha Ana Rosa Pinto Quidute Darlan da Silva Cândido Ângela Maria de Souza Ponciano Marta Maria de França Fonteles Maria de Fátima Oliveira Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions Revista da Sociedade Brasileira de Medicina Tropical Chagas disease Pharmaceutical care Pharmacotherapy |
| title | Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
| title_full | Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
| title_fullStr | Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
| title_full_unstemmed | Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
| title_short | Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions |
| title_sort | pharmacotherapeutic follow up of patients with chagas disease using benznidazole drug related problems and pharmaceutical interventions |
| topic | Chagas disease Pharmaceutical care Pharmacotherapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300334&lng=en&tlng=en |
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