Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection

Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection

Tripartite-motif 21 (TRIM21) is thought to regulate the type I interferon (IFN) response to virus pathogens and serve as a cytosolic Fc receptor for immunoglobulin. Since herpes simplex virus (HSV)-1 is sensitive to type I IFN and neutralizing antibody, we investigated the role of TRIM21 in response...

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Bibliographic Details
Main Authors: Amanda Berube, Grzegorz B. Gmyrek, Derek J. Royer, Daniel J. J. Carr
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
HSV-1
cornea
trigeminal ganglia
T cells
interferon-γ
interferon stimulatory genes
Online Access:https://www.mdpi.com/1999-4915/14/3/589

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