Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort
Abstract Objective To evaluate the association between body composition and subsequent risk of the major gynecologic malignancies. Methods This is a prospective analysis of participants from the UK Biobank. We measured baseline body composition and confirmed cancer diagnosis through linkage to cance...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3925 |
| _version_ | 1818847227834007552 |
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| author | Peng Yun Bin Xia Xiao‐hui Tian Ting Gong An‐ran Liu Jin‐qiu Yuan Fang‐ping Li |
| author_facet | Peng Yun Bin Xia Xiao‐hui Tian Ting Gong An‐ran Liu Jin‐qiu Yuan Fang‐ping Li |
| author_sort | Peng Yun |
| collection | DOAJ |
| description | Abstract Objective To evaluate the association between body composition and subsequent risk of the major gynecologic malignancies. Methods This is a prospective analysis of participants from the UK Biobank. We measured baseline body composition and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. Results We document 1430 cases of the top three gynecologic malignancies (uterine corpus cancer 847 cases, ovarian cancer 514 cases, and cervical cancer 69 cases) from 245,084 female participants (75,307 were premenopausal and 169,777 were postmenopausal). For premenopausal women, whole body fat‐free mass (WBFFM) was associated with an increased risk of uterine corpus cancer (Adjusted HR per unit increase 1.04, 95% CI 1.02–1.06). For postmenopausal women, compared with the first quartile, the fourth quartile of WBFFM and whole body fat mass(WBFM) was associated with 2.16 (95% CI 1.49–3.13) times and 1.89 (95% CI 1.31–2.72) times of increased uterine corpus cancer risk, respectively. Regarding the distribution of body fat mass (FM)/fat‐free mass (FFM), FFM distributed in the trunk was associate with increased uterine corpus cancer risk in premenopausal (HR 1.18,95% CI 1.07–1.31) and postmenopausal women (HR 1.13,95% CI 1.09–1.18). Meanwhile, FM/FFM distributed in the limbs present an U‐shaped associations with uterine corpus cancer risk. We did not observe any association between aforementioned body composition indices with ovarian or cervical cancer. Conclusion FM is associated with an increased risk of uterine corpus cancer in postmenopausal women. Meanwhile, FFM is found to be a risk factor for uterine corpus cancer in both premenopausal and postmenopausal women. No association of body composition with ovarian or cervical cancer was observed. |
| first_indexed | 2024-12-19T05:58:06Z |
| format | Article |
| id | doaj.art-74334d72bbc04d75b35fb55985f05eeb |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-19T05:58:06Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-74334d72bbc04d75b35fb55985f05eeb2022-12-21T20:33:23ZengWileyCancer Medicine2045-76342021-07-0110134522453110.1002/cam4.3925Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohortPeng Yun0Bin Xia1Xiao‐hui Tian2Ting Gong3An‐ran Liu4Jin‐qiu Yuan5Fang‐ping Li6Department of Endocrinology The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaClinical medicine research center The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaDepartment of Obstetrics and Gynecology The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaDepartment of Radiology The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaDepartment of Nutriology The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaClinical medicine research center The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaDepartment of Endocrinology The Seventh Affiliated Hospital of Sun Yat‐sen University Shenzhen ChinaAbstract Objective To evaluate the association between body composition and subsequent risk of the major gynecologic malignancies. Methods This is a prospective analysis of participants from the UK Biobank. We measured baseline body composition and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. Results We document 1430 cases of the top three gynecologic malignancies (uterine corpus cancer 847 cases, ovarian cancer 514 cases, and cervical cancer 69 cases) from 245,084 female participants (75,307 were premenopausal and 169,777 were postmenopausal). For premenopausal women, whole body fat‐free mass (WBFFM) was associated with an increased risk of uterine corpus cancer (Adjusted HR per unit increase 1.04, 95% CI 1.02–1.06). For postmenopausal women, compared with the first quartile, the fourth quartile of WBFFM and whole body fat mass(WBFM) was associated with 2.16 (95% CI 1.49–3.13) times and 1.89 (95% CI 1.31–2.72) times of increased uterine corpus cancer risk, respectively. Regarding the distribution of body fat mass (FM)/fat‐free mass (FFM), FFM distributed in the trunk was associate with increased uterine corpus cancer risk in premenopausal (HR 1.18,95% CI 1.07–1.31) and postmenopausal women (HR 1.13,95% CI 1.09–1.18). Meanwhile, FM/FFM distributed in the limbs present an U‐shaped associations with uterine corpus cancer risk. We did not observe any association between aforementioned body composition indices with ovarian or cervical cancer. Conclusion FM is associated with an increased risk of uterine corpus cancer in postmenopausal women. Meanwhile, FFM is found to be a risk factor for uterine corpus cancer in both premenopausal and postmenopausal women. No association of body composition with ovarian or cervical cancer was observed.https://doi.org/10.1002/cam4.3925body compositioncohort studygynecological malignancyUK Biobank |
| spellingShingle | Peng Yun Bin Xia Xiao‐hui Tian Ting Gong An‐ran Liu Jin‐qiu Yuan Fang‐ping Li Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort Cancer Medicine body composition cohort study gynecological malignancy UK Biobank |
| title | Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort |
| title_full | Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort |
| title_fullStr | Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort |
| title_full_unstemmed | Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort |
| title_short | Body composition and risk of major gynecologic malignancies: Results from the UK Biobank prospective cohort |
| title_sort | body composition and risk of major gynecologic malignancies results from the uk biobank prospective cohort |
| topic | body composition cohort study gynecological malignancy UK Biobank |
| url | https://doi.org/10.1002/cam4.3925 |
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