Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria
Introduction and objective Loss to follow-up (LTFU) along the TB care cascade is a barrier to TB control because of sustained TB transmission including resistant strains, high mortality and increased spread of DRTB strains. Understanding common reasons for LTFU and their timing could help target int...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2022-06-01
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| Series: | Journal of Pre-Clinical and Clinical Research |
| Subjects: | |
| Online Access: | https://www.jpccr.eu/Timing-and-reasons-for-lost-to-follow-up-among-patients-on-6-month-standardized-anti,150601,0,2.html |
| _version_ | 1797870247064109056 |
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| author | Abiola Victor Adepoju Ademola Adelekan Olusola Adedeji Adejumo |
| author_facet | Abiola Victor Adepoju Ademola Adelekan Olusola Adedeji Adejumo |
| author_sort | Abiola Victor Adepoju |
| collection | DOAJ |
| description | Introduction and objective
Loss to follow-up (LTFU) along the TB care cascade is a barrier to TB control because of
sustained TB transmission including resistant strains, high mortality and increased spread of DRTB strains. Understanding common reasons for LTFU and their timing could help target interventions to improve adherence to TB treatment.
Material and methods
A cross-sectional study using pre-tested questionnaires were administered by phone interviews to
90 TB patients receiving treatment between January – December 2020 who were LTFU while on TB treatment in 31 health facilities across three States in South West Nigeria. The focus of the interviews was to determine the reasons why they were LTFU. Interviewers contacted treatment supporters when patients could not be reached. Clinical and socio-demographic information, such as age, sex and HIV status were extracted from treatment registers
Results
The mean age of patients was 42.6 years (16–90) and SD=17.2. The majority 73 (81%) of LTFU were male, while Ogun State had the highest number – 35 (38.9%), LTFU was highest during the first month on treatment – 60 (66.7%), among HIV negative – 63 (70%), and those who had not been treated previously for TB – 85 (94.4%). The most common reason for LTFU among TB patients on treatment was death – 23(25.6%), followed by lack of transport – 16 (17.8%), and religious beliefs – 12 (13.3%).
Conclusions
The study suggests a high mortality among patients receiving treatment who may have been classified as LTFU. Interventions to reduce mortality and increase coverage of TB treatment facilities, thus bringing care closer to patients, is necessary. It is suggested that 30-day adherence calendars should be used to improve adherence counselling in the first one month on treatment to minimize early LTFU among TB patients. |
| first_indexed | 2024-04-10T00:25:26Z |
| format | Article |
| id | doaj.art-743367db03434a3faa129e61728a7d50 |
| institution | Directory Open Access Journal |
| issn | 1898-2395 1898-7516 |
| language | English |
| last_indexed | 2024-04-10T00:25:26Z |
| publishDate | 2022-06-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Journal of Pre-Clinical and Clinical Research |
| spelling | doaj.art-743367db03434a3faa129e61728a7d502023-03-15T10:41:32ZengInstitute of Rural HealthJournal of Pre-Clinical and Clinical Research1898-23951898-75162022-06-01162343710.26444/jpccr/150601150601Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in NigeriaAbiola Victor Adepoju0https://orcid.org/0000-0001-8379-1001Ademola Adelekan1https://orcid.org/0000-0001-5729-6824Olusola Adedeji Adejumo2https://orcid.org/0000-0001-8946-3244Jhpiego Nigeria (an affiliate of John Hopkins University), NigeriaBluegate Research Institute, Ibadan, NigeriaState Ministry of Health, Lagos, NigeriaIntroduction and objective Loss to follow-up (LTFU) along the TB care cascade is a barrier to TB control because of sustained TB transmission including resistant strains, high mortality and increased spread of DRTB strains. Understanding common reasons for LTFU and their timing could help target interventions to improve adherence to TB treatment. Material and methods A cross-sectional study using pre-tested questionnaires were administered by phone interviews to 90 TB patients receiving treatment between January – December 2020 who were LTFU while on TB treatment in 31 health facilities across three States in South West Nigeria. The focus of the interviews was to determine the reasons why they were LTFU. Interviewers contacted treatment supporters when patients could not be reached. Clinical and socio-demographic information, such as age, sex and HIV status were extracted from treatment registers Results The mean age of patients was 42.6 years (16–90) and SD=17.2. The majority 73 (81%) of LTFU were male, while Ogun State had the highest number – 35 (38.9%), LTFU was highest during the first month on treatment – 60 (66.7%), among HIV negative – 63 (70%), and those who had not been treated previously for TB – 85 (94.4%). The most common reason for LTFU among TB patients on treatment was death – 23(25.6%), followed by lack of transport – 16 (17.8%), and religious beliefs – 12 (13.3%). Conclusions The study suggests a high mortality among patients receiving treatment who may have been classified as LTFU. Interventions to reduce mortality and increase coverage of TB treatment facilities, thus bringing care closer to patients, is necessary. It is suggested that 30-day adherence calendars should be used to improve adherence counselling in the first one month on treatment to minimize early LTFU among TB patients.https://www.jpccr.eu/Timing-and-reasons-for-lost-to-follow-up-among-patients-on-6-month-standardized-anti,150601,0,2.htmltuberculosislost to follow-updirectly observed therapy short courseanti-tb drugs |
| spellingShingle | Abiola Victor Adepoju Ademola Adelekan Olusola Adedeji Adejumo Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria Journal of Pre-Clinical and Clinical Research tuberculosis lost to follow-up directly observed therapy short course anti-tb drugs |
| title | Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria |
| title_full | Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria |
| title_fullStr | Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria |
| title_full_unstemmed | Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria |
| title_short | Timing and reasons for lost to follow-up among patients on 6-month standardized anti-TB treatment in Nigeria |
| title_sort | timing and reasons for lost to follow up among patients on 6 month standardized anti tb treatment in nigeria |
| topic | tuberculosis lost to follow-up directly observed therapy short course anti-tb drugs |
| url | https://www.jpccr.eu/Timing-and-reasons-for-lost-to-follow-up-among-patients-on-6-month-standardized-anti,150601,0,2.html |
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