Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study
Abstract Background Whole-body diffusion-weighted magnetic resonance is being developed as a tool for assessing tumor spread. Patients with known primary tumors require meticulous evaluation to assess metastasis for better staging; we attempted to detect bony metastasis without radiation exposure. O...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-023-01012-1 |
| _version_ | 1797850166654402560 |
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| author | Heba Tollah Ahmed Ibrahim Eltonbary Nehal Mohamed Elmashad Sameh Ahmed Khodair Rania Sobhy Abou Khadrah |
| author_facet | Heba Tollah Ahmed Ibrahim Eltonbary Nehal Mohamed Elmashad Sameh Ahmed Khodair Rania Sobhy Abou Khadrah |
| author_sort | Heba Tollah Ahmed Ibrahim Eltonbary |
| collection | DOAJ |
| description | Abstract Background Whole-body diffusion-weighted magnetic resonance is being developed as a tool for assessing tumor spread. Patients with known primary tumors require meticulous evaluation to assess metastasis for better staging; we attempted to detect bony metastasis without radiation exposure. Our study's goal was to use whole-body diffusion-weighted imaging with background body signal suppression (WB-DWBIS) to evaluate bony metastasis in confirmed patients who have primary tumors. Results Our study included 90 patients with known primary cancer, 10 patients were excluded as they had no bony metastasis, from 80 patients: 36 (45.0%) having one site of metastasis, 36 (45%) having two sites of metastasis, and 8 (10.0%) having three sites of metastasis. 56 (70.0%) of the metastasis sites were bony metastasis, and 76 were mixed both bony and non-bony, including 32(40.0%) lung, 16 (20.0%) liver, and 28 (35%) lymph nodes. Sensitivity of bone scanning in detecting metastasis was as follows: 95.1% sensitivity and 92.0% accuracy, while that of whole-body diffusion-weighted image with background signals suppression was 94.8% sensitivity and 91.7% accuracy, WB-DWBIS inter-observer agreement in the detection of bony metastatic deposits in cancer patients was good (0.7 45, agreement = 93.2%). Conclusions Using WB-DWBIS images, bone lesion identification and characterization (site and number) were improved, producing outcomes similar to bone scanning without the use of ionizing radiation. |
| first_indexed | 2024-04-09T18:56:01Z |
| format | Article |
| id | doaj.art-74355b577e0844e5a53f58b67206761a |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-04-09T18:56:01Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-74355b577e0844e5a53f58b67206761a2023-04-09T11:11:24ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622023-04-0154111010.1186/s43055-023-01012-1Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot studyHeba Tollah Ahmed Ibrahim Eltonbary0Nehal Mohamed Elmashad1Sameh Ahmed Khodair2Rania Sobhy Abou Khadrah3Department of Radiology Faculty of Medicine, Faculty of Medicine, Tanta University Hospital, Tanta UniversityFaculty of Medicine, Tanta University Hospital, Tanta UniversityFaculty of Medicine, Tanta University Hospital, Tanta UniversityRadiology department, Faculty of Medicine, College of Medicine, Tanta University Hospital, Tanta UniversityAbstract Background Whole-body diffusion-weighted magnetic resonance is being developed as a tool for assessing tumor spread. Patients with known primary tumors require meticulous evaluation to assess metastasis for better staging; we attempted to detect bony metastasis without radiation exposure. Our study's goal was to use whole-body diffusion-weighted imaging with background body signal suppression (WB-DWBIS) to evaluate bony metastasis in confirmed patients who have primary tumors. Results Our study included 90 patients with known primary cancer, 10 patients were excluded as they had no bony metastasis, from 80 patients: 36 (45.0%) having one site of metastasis, 36 (45%) having two sites of metastasis, and 8 (10.0%) having three sites of metastasis. 56 (70.0%) of the metastasis sites were bony metastasis, and 76 were mixed both bony and non-bony, including 32(40.0%) lung, 16 (20.0%) liver, and 28 (35%) lymph nodes. Sensitivity of bone scanning in detecting metastasis was as follows: 95.1% sensitivity and 92.0% accuracy, while that of whole-body diffusion-weighted image with background signals suppression was 94.8% sensitivity and 91.7% accuracy, WB-DWBIS inter-observer agreement in the detection of bony metastatic deposits in cancer patients was good (0.7 45, agreement = 93.2%). Conclusions Using WB-DWBIS images, bone lesion identification and characterization (site and number) were improved, producing outcomes similar to bone scanning without the use of ionizing radiation.https://doi.org/10.1186/s43055-023-01012-1Whole-bodyDiffusion WIMetastasisBackground signals suppression |
| spellingShingle | Heba Tollah Ahmed Ibrahim Eltonbary Nehal Mohamed Elmashad Sameh Ahmed Khodair Rania Sobhy Abou Khadrah Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study The Egyptian Journal of Radiology and Nuclear Medicine Whole-body Diffusion WI Metastasis Background signals suppression |
| title | Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study |
| title_full | Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study |
| title_fullStr | Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study |
| title_full_unstemmed | Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study |
| title_short | Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study |
| title_sort | suppression of background body signals in whole body diffusion weighted imaging for detection of bony metastases a pilot study |
| topic | Whole-body Diffusion WI Metastasis Background signals suppression |
| url | https://doi.org/10.1186/s43055-023-01012-1 |
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