A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study
Background Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of non-alcoholic fatty liver disease (NAFLD). However, the combined role of these factors in early screening of NAFLD has not been i...
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PeerJ Inc.
2022-03-01
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| author | Min Wang Minxian Wang Ru Zhang Liuxin Zhang Yajie Ding Zongzhe Tang Haozhi Fan Hongliang Wang Wei Zhang Yue Chen Jie Wang |
| author_facet | Min Wang Minxian Wang Ru Zhang Liuxin Zhang Yajie Ding Zongzhe Tang Haozhi Fan Hongliang Wang Wei Zhang Yue Chen Jie Wang |
| author_sort | Min Wang |
| collection | DOAJ |
| description | Background Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of non-alcoholic fatty liver disease (NAFLD). However, the combined role of these factors in early screening of NAFLD has not been investigated. We aimed to de lineate this role in a community-based population. Methods Binary logistic regression was used to explore the correlations of SUA, ALT and WC with NAFLD risk. The goodness of fit and discriminative ability of the model were evaluated by the Hosmer-Lemeshow test and area under the receiver operating characteristic curve (AUROC), respectively. Results Logistic regression analysis indicated that elevated SUA (adjusted odds ratio (OR) = 2.44, 95% confidence interval (CI) [1.76–3.38]), ALT (adjusted OR = 4.98, 95% CI [3.41–7.27]) and WC (adjusted OR = 3.22, 95% CI [2.01–5.16]) were facilitating factors for incident NAFLD after fully adjusted for related confounders. In addition, the risk of NAFLD followed linear trend s with increasing levels of these three indicators (all Ptrend < 0.001). The risk assessment model consisting of SUA, ALT, WC and demographics showed useful discrimination by AUROC being 0.825 (95% CI [0.811–0.838]) and good performance of calibration (P = 0.561). Conclusions SUA, ALT and WC were all associated with NAFLD, independent of known risk factors. The simple model composed of these indicators showed good performance in the Chinese population, which may be applicable for appraisal of NAFLD risk in primary healthcare. |
| first_indexed | 2024-03-09T08:09:30Z |
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| language | English |
| last_indexed | 2024-03-09T08:09:30Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-7437867253784c8fa1a719d018f84f6b2023-12-02T23:30:34ZengPeerJ Inc.PeerJ2167-83592022-03-0110e1302210.7717/peerj.13022A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based studyMin Wang0Minxian Wang1Ru Zhang2Liuxin Zhang3Yajie Ding4Zongzhe Tang5Haozhi Fan6Hongliang Wang7Wei Zhang8Yue Chen9Jie Wang10School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaAffiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Information, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaMofan West Road Community Health Service Center, Nanjing, Jiangsu, ChinaDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, ChinaSchool of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Nursing, Nanjing Medical University, Nanjing, Jiangsu, ChinaBackground Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of non-alcoholic fatty liver disease (NAFLD). However, the combined role of these factors in early screening of NAFLD has not been investigated. We aimed to de lineate this role in a community-based population. Methods Binary logistic regression was used to explore the correlations of SUA, ALT and WC with NAFLD risk. The goodness of fit and discriminative ability of the model were evaluated by the Hosmer-Lemeshow test and area under the receiver operating characteristic curve (AUROC), respectively. Results Logistic regression analysis indicated that elevated SUA (adjusted odds ratio (OR) = 2.44, 95% confidence interval (CI) [1.76–3.38]), ALT (adjusted OR = 4.98, 95% CI [3.41–7.27]) and WC (adjusted OR = 3.22, 95% CI [2.01–5.16]) were facilitating factors for incident NAFLD after fully adjusted for related confounders. In addition, the risk of NAFLD followed linear trend s with increasing levels of these three indicators (all Ptrend < 0.001). The risk assessment model consisting of SUA, ALT, WC and demographics showed useful discrimination by AUROC being 0.825 (95% CI [0.811–0.838]) and good performance of calibration (P = 0.561). Conclusions SUA, ALT and WC were all associated with NAFLD, independent of known risk factors. The simple model composed of these indicators showed good performance in the Chinese population, which may be applicable for appraisal of NAFLD risk in primary healthcare.https://peerj.com/articles/13022.pdfNon-alcoholic fatty liver disease (NAFLD)Risk assessment modelSerum uric acid (SUA)Alanine aminotransferase (ALT)Waist circumference (WC) |
| spellingShingle | Min Wang Minxian Wang Ru Zhang Liuxin Zhang Yajie Ding Zongzhe Tang Haozhi Fan Hongliang Wang Wei Zhang Yue Chen Jie Wang A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study PeerJ Non-alcoholic fatty liver disease (NAFLD) Risk assessment model Serum uric acid (SUA) Alanine aminotransferase (ALT) Waist circumference (WC) |
| title | A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study |
| title_full | A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study |
| title_fullStr | A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study |
| title_full_unstemmed | A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study |
| title_short | A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study |
| title_sort | combined association of serum uric acid alanine aminotransferase and waist circumference with non alcoholic fatty liver disease a community based study |
| topic | Non-alcoholic fatty liver disease (NAFLD) Risk assessment model Serum uric acid (SUA) Alanine aminotransferase (ALT) Waist circumference (WC) |
| url | https://peerj.com/articles/13022.pdf |
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