Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen‐Induced Apoptosis in Rhabdomyosarcoma Cells

Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen‐Induced Apoptosis in Rhabdomyosarcoma Cells

Abstract Fibrillar collagens promote cell proliferation, migration, and survival in various epithelial cancers and are generally associated with tumor aggressiveness. However, the impact of fibrillar collagens on soft tissue sarcoma behavior remains poorly understood. Unexpectedly, this study finds...

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Bibliographic Details
Main Authors: Jordi Gonzalez‐Molina, Katharina Miria Kirchhof, Bhavik Rathod, Lidia Moyano‐Galceran, Maria Calvo‐Noriega, Georgia Kokaraki, Astrid Bjørkøy, Monika Ehnman, Joseph W. Carlson, Kaisa Lehti
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Advanced Science
Subjects:
apoptosis
collagen microarchitecture
extracellular matrix
mechanical confinement
rhabdomyosarcoma
Online Access:https://doi.org/10.1002/advs.202202552

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