Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease.
The biologically active pancreatic hormone peptide islet amyloid polypeptide (IAPP) regulates brain functions such as appetite and cognition. It also plays a role in clearance of amyloid beta (Aβ), a peptide implicated in the dementia disorder Alzheimer's disease (AD). If IAPP becomes modified,...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0218561 |
| _version_ | 1818590347401363456 |
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| author | Nina Schultz Shorena Janelidze Elin Byman Lennart Minthon Katarina Nägga Oskar Hansson Malin Wennström |
| author_facet | Nina Schultz Shorena Janelidze Elin Byman Lennart Minthon Katarina Nägga Oskar Hansson Malin Wennström |
| author_sort | Nina Schultz |
| collection | DOAJ |
| description | The biologically active pancreatic hormone peptide islet amyloid polypeptide (IAPP) regulates brain functions such as appetite and cognition. It also plays a role in clearance of amyloid beta (Aβ), a peptide implicated in the dementia disorder Alzheimer's disease (AD). If IAPP becomes modified, it loses its biological activity and starts to aggregate. Such aggregations have been found in the AD brain and decreased plasma levels of the unmodified IAPP (uIAPP) have been shown in the same patients. In the current study, we analyze levels of uIAPP and total IAPP (unmodified and modified) in cerebrospinal fluid (CSF) to investigate its potential as a biomarker for AD. We found no differences in neither CSF nor plasma levels of uIAPP or total IAPP in AD patients compared to cognitive healthy individuals (NC). The levels of uIAPP in CSF of NC were positively correlated with uIAPP in plasma, Q-albumin and albumin levels in CSF, but negatively correlated with CSF levels of t-tau and p-tau. These findings were not seen in AD patients. Levels of total CSF IAPP correlated positively with total Q-albumin and albumin levels in CSF in both AD and NC. In addition, total plasma IAPP correlated positively with CSF t-tau and p-tau in NC and negatively with CSF Aβ42 in AD patients. To conclude, our studies did not find evidence supporting the use of CSF IAPP as an AD biomarker. However, our findings, indicating a compromised translocation of uIAPP in and out of the brain in AD patients as well as the correlations between total plasma IAPP and AD biomarkers, encourage further research on the role for IAPP in AD. |
| first_indexed | 2024-12-16T09:55:06Z |
| format | Article |
| id | doaj.art-74398c8f83994e7b9cbdc1e47147b7f6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T09:55:06Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-74398c8f83994e7b9cbdc1e47147b7f62022-12-21T22:35:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01146e021856110.1371/journal.pone.0218561Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease.Nina SchultzShorena JanelidzeElin BymanLennart MinthonKatarina NäggaOskar HanssonMalin WennströmThe biologically active pancreatic hormone peptide islet amyloid polypeptide (IAPP) regulates brain functions such as appetite and cognition. It also plays a role in clearance of amyloid beta (Aβ), a peptide implicated in the dementia disorder Alzheimer's disease (AD). If IAPP becomes modified, it loses its biological activity and starts to aggregate. Such aggregations have been found in the AD brain and decreased plasma levels of the unmodified IAPP (uIAPP) have been shown in the same patients. In the current study, we analyze levels of uIAPP and total IAPP (unmodified and modified) in cerebrospinal fluid (CSF) to investigate its potential as a biomarker for AD. We found no differences in neither CSF nor plasma levels of uIAPP or total IAPP in AD patients compared to cognitive healthy individuals (NC). The levels of uIAPP in CSF of NC were positively correlated with uIAPP in plasma, Q-albumin and albumin levels in CSF, but negatively correlated with CSF levels of t-tau and p-tau. These findings were not seen in AD patients. Levels of total CSF IAPP correlated positively with total Q-albumin and albumin levels in CSF in both AD and NC. In addition, total plasma IAPP correlated positively with CSF t-tau and p-tau in NC and negatively with CSF Aβ42 in AD patients. To conclude, our studies did not find evidence supporting the use of CSF IAPP as an AD biomarker. However, our findings, indicating a compromised translocation of uIAPP in and out of the brain in AD patients as well as the correlations between total plasma IAPP and AD biomarkers, encourage further research on the role for IAPP in AD.https://doi.org/10.1371/journal.pone.0218561 |
| spellingShingle | Nina Schultz Shorena Janelidze Elin Byman Lennart Minthon Katarina Nägga Oskar Hansson Malin Wennström Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease. PLoS ONE |
| title | Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease. |
| title_full | Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease. |
| title_fullStr | Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease. |
| title_full_unstemmed | Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease. |
| title_short | Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease. |
| title_sort | levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with alzheimer s disease |
| url | https://doi.org/10.1371/journal.pone.0218561 |
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