Current Insights to Regulation and Role of Telomerase in Human Diseases
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and other associated proteins that...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-02-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3921/6/1/17 |
| _version_ | 1827836914129960960 |
|---|---|
| author | Mert Burak Ozturk Yinghui Li Vinay Tergaonkar |
| author_facet | Mert Burak Ozturk Yinghui Li Vinay Tergaonkar |
| author_sort | Mert Burak Ozturk |
| collection | DOAJ |
| description | The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and other associated proteins that function to elongate telomeres localized at the end of the chromosomes. While reactivation of telomerase is a major hallmark of most cancers, together with the synergistic activation of other oncogenic signals, deficiency in telomerase and telomeric proteins might lead to aging and senescence-associated disorders. Therefore, it is critically important to understand the canonical as well as non-canonical functions of telomerase through TERT to develop a therapeutic strategy against telomerase-related diseases. In this review, we shed light on the regulation and function of telomerase, and current therapeutic strategies against telomerase in cancer and age-related diseases. |
| first_indexed | 2024-03-12T06:35:08Z |
| format | Article |
| id | doaj.art-743b9a2785074932bc0a03be22c50433 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T06:35:08Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-743b9a2785074932bc0a03be22c504332023-09-03T01:23:42ZengMDPI AGAntioxidants2076-39212017-02-01611710.3390/antiox6010017antiox6010017Current Insights to Regulation and Role of Telomerase in Human DiseasesMert Burak Ozturk0Yinghui Li1Vinay Tergaonkar2Division of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, SingaporeDivision of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, SingaporeDivision of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, SingaporeThe telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and other associated proteins that function to elongate telomeres localized at the end of the chromosomes. While reactivation of telomerase is a major hallmark of most cancers, together with the synergistic activation of other oncogenic signals, deficiency in telomerase and telomeric proteins might lead to aging and senescence-associated disorders. Therefore, it is critically important to understand the canonical as well as non-canonical functions of telomerase through TERT to develop a therapeutic strategy against telomerase-related diseases. In this review, we shed light on the regulation and function of telomerase, and current therapeutic strategies against telomerase in cancer and age-related diseases.http://www.mdpi.com/2076-3921/6/1/17telomerasetelomerase reverse transcriptase (TERT)hTERT promoter mutationstelomerase RNA component (TERC)telomerecancerage-related diseases |
| spellingShingle | Mert Burak Ozturk Yinghui Li Vinay Tergaonkar Current Insights to Regulation and Role of Telomerase in Human Diseases Antioxidants telomerase telomerase reverse transcriptase (TERT) hTERT promoter mutations telomerase RNA component (TERC) telomere cancer age-related diseases |
| title | Current Insights to Regulation and Role of Telomerase in Human Diseases |
| title_full | Current Insights to Regulation and Role of Telomerase in Human Diseases |
| title_fullStr | Current Insights to Regulation and Role of Telomerase in Human Diseases |
| title_full_unstemmed | Current Insights to Regulation and Role of Telomerase in Human Diseases |
| title_short | Current Insights to Regulation and Role of Telomerase in Human Diseases |
| title_sort | current insights to regulation and role of telomerase in human diseases |
| topic | telomerase telomerase reverse transcriptase (TERT) hTERT promoter mutations telomerase RNA component (TERC) telomere cancer age-related diseases |
| url | http://www.mdpi.com/2076-3921/6/1/17 |
| work_keys_str_mv | AT mertburakozturk currentinsightstoregulationandroleoftelomeraseinhumandiseases AT yinghuili currentinsightstoregulationandroleoftelomeraseinhumandiseases AT vinaytergaonkar currentinsightstoregulationandroleoftelomeraseinhumandiseases |