Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study
Introduction: Blockade of the renin-angiotensin system (RAS) is a critical approach to the management of hypertension, especially in proteinuric patients. It is well proven that the direct renin inhibitor aliskiren shows comparable clinical efficacy to the angiotensin II receptor blocker valsartan o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2013-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312465219 |
| _version_ | 1797288972498501632 |
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| author | Georgios Spanos Rigas Kalaitzidis Despina Karasavvidou Kosmas Pappas Kostas C Siamopoulos |
| author_facet | Georgios Spanos Rigas Kalaitzidis Despina Karasavvidou Kosmas Pappas Kostas C Siamopoulos |
| author_sort | Georgios Spanos |
| collection | DOAJ |
| description | Introduction: Blockade of the renin-angiotensin system (RAS) is a critical approach to the management of hypertension, especially in proteinuric patients. It is well proven that the direct renin inhibitor aliskiren shows comparable clinical efficacy to the angiotensin II receptor blocker valsartan on blood pressure control and albuminuria. However, there is only limited data on the hand-to-hand effectiveness of these two RAS blockers in improving arterial stiffness. We tested whether aliskiren or valsartan would improve arterial stiffness in hypertensive patients with albuminuria who are already on antihypertensive therapy. Material and methods: Thirty-four patients with hypertension and albuminuria < 1 g, after a wash-out period of three weeks, were randomized to aliskiren or valsartan in a 24-week randomized parallel-group study. Results: A nonsignificant difference in blood pressure was seen between the two treatment groups. Albuminuria was significantly reduced in both groups (56% for the aliskiren group, p < 0.05, and 38% for the valsartan group, p < 0.05). Only valsartan but not aliskiren significantly reduced carotid-femoral pulse wave velocity (–1.1 ± 0.8 m/s ( p = 0.02) for valsartan and +0.1 ± 0.7 m/s (ns) for aliskiren). Conclusion: The results of our study showed that valsartan improves arterial stiffness to a significantly greater extent than aliskiren, despite a similar antihypertensive and antiproteinuric effect. |
| first_indexed | 2024-03-07T18:57:25Z |
| format | Article |
| id | doaj.art-743e2ecdba7c4208b22a32e7fd3b0c9f |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:57:25Z |
| publishDate | 2013-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-743e2ecdba7c4208b22a32e7fd3b0c9f2024-03-02T00:08:16ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762013-12-011410.1177/1470320312465219Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group studyGeorgios SpanosRigas KalaitzidisDespina KarasavvidouKosmas PappasKostas C SiamopoulosIntroduction: Blockade of the renin-angiotensin system (RAS) is a critical approach to the management of hypertension, especially in proteinuric patients. It is well proven that the direct renin inhibitor aliskiren shows comparable clinical efficacy to the angiotensin II receptor blocker valsartan on blood pressure control and albuminuria. However, there is only limited data on the hand-to-hand effectiveness of these two RAS blockers in improving arterial stiffness. We tested whether aliskiren or valsartan would improve arterial stiffness in hypertensive patients with albuminuria who are already on antihypertensive therapy. Material and methods: Thirty-four patients with hypertension and albuminuria < 1 g, after a wash-out period of three weeks, were randomized to aliskiren or valsartan in a 24-week randomized parallel-group study. Results: A nonsignificant difference in blood pressure was seen between the two treatment groups. Albuminuria was significantly reduced in both groups (56% for the aliskiren group, p < 0.05, and 38% for the valsartan group, p < 0.05). Only valsartan but not aliskiren significantly reduced carotid-femoral pulse wave velocity (–1.1 ± 0.8 m/s ( p = 0.02) for valsartan and +0.1 ± 0.7 m/s (ns) for aliskiren). Conclusion: The results of our study showed that valsartan improves arterial stiffness to a significantly greater extent than aliskiren, despite a similar antihypertensive and antiproteinuric effect.https://doi.org/10.1177/1470320312465219 |
| spellingShingle | Georgios Spanos Rigas Kalaitzidis Despina Karasavvidou Kosmas Pappas Kostas C Siamopoulos Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study Journal of the Renin-Angiotensin-Aldosterone System |
| title | Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study |
| title_full | Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study |
| title_fullStr | Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study |
| title_full_unstemmed | Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study |
| title_short | Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study |
| title_sort | efficacy of aliskiren and valsartan in hypertensive patients with albuminuria a randomized parallel group study |
| url | https://doi.org/10.1177/1470320312465219 |
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