INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS
Abstract. Using modern immunological methods of studies, we investigated some immunopathogenetic aspects of rheumatoid arthritis complicated by chronic herpesvirus infection. It was established that both rheumatoid arthritis, and chronic herpesvirus infection are accompanied by pronounced imbalance...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/465 |
| _version_ | 1797198023572324352 |
|---|---|
| author | N. A. Pronina V. S. Sviridova E. N. Kologrivova L. V. Еliseeva I. O. Naslednikova O. I. Urazova V. V. Novitsky O. V. Voronkova N. A. Sukhalentseva E. B. Gorbunova |
| author_facet | N. A. Pronina V. S. Sviridova E. N. Kologrivova L. V. Еliseeva I. O. Naslednikova O. I. Urazova V. V. Novitsky O. V. Voronkova N. A. Sukhalentseva E. B. Gorbunova |
| author_sort | N. A. Pronina |
| collection | DOAJ |
| description | Abstract. Using modern immunological methods of studies, we investigated some immunopathogenetic aspects of rheumatoid arthritis complicated by chronic herpesvirus infection. It was established that both rheumatoid arthritis, and chronic herpesvirus infection are accompanied by pronounced imbalance in production of immunoregulatory Th1/Th2-cytokines produced in immunocompetent cells of peripheral blood. In case of rheumatoid arthritis combined with herpes simplex infection, IL-2 and IFNγγ levels were decreased, whereas IL-4 и IL-6 levels proved to be increased, as compared with isolated diseases under study. |
| first_indexed | 2024-03-08T05:50:43Z |
| format | Article |
| id | doaj.art-743e87519dbd4af2b88301538f9ed66d |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:16Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-743e87519dbd4af2b88301538f9ed66d2024-04-22T13:07:37ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01111919410.15789/1563-0625-2009-1-91-94462INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITISN. A. Pronina0V. S. Sviridova1E. N. Kologrivova2L. V. Еliseeva3I. O. Naslednikova4O. I. Urazova5V. V. Novitsky6O. V. Voronkova7N. A. Sukhalentseva8E. B. Gorbunova9ГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскГОУ ВПО «Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию», г. ТомскAbstract. Using modern immunological methods of studies, we investigated some immunopathogenetic aspects of rheumatoid arthritis complicated by chronic herpesvirus infection. It was established that both rheumatoid arthritis, and chronic herpesvirus infection are accompanied by pronounced imbalance in production of immunoregulatory Th1/Th2-cytokines produced in immunocompetent cells of peripheral blood. In case of rheumatoid arthritis combined with herpes simplex infection, IL-2 and IFNγγ levels were decreased, whereas IL-4 и IL-6 levels proved to be increased, as compared with isolated diseases under study.https://www.mimmun.ru/mimmun/article/view/465herpes simplex virusrheumatoid arthritiscytokines |
| spellingShingle | N. A. Pronina V. S. Sviridova E. N. Kologrivova L. V. Еliseeva I. O. Naslednikova O. I. Urazova V. V. Novitsky O. V. Voronkova N. A. Sukhalentseva E. B. Gorbunova INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS Медицинская иммунология herpes simplex virus rheumatoid arthritis cytokines |
| title | INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS |
| title_full | INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS |
| title_fullStr | INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS |
| title_full_unstemmed | INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS |
| title_short | INFLUENCE OF HERPES SIMPLEX VIRUS PERSISTENCE UPON PRODUCTION OF CYTOKINES BY IMMUNOCOMPETENT CELLS IN RHEUMATOID ARTHRITIS |
| title_sort | influence of herpes simplex virus persistence upon production of cytokines by immunocompetent cells in rheumatoid arthritis |
| topic | herpes simplex virus rheumatoid arthritis cytokines |
| url | https://www.mimmun.ru/mimmun/article/view/465 |
| work_keys_str_mv | AT napronina influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT vssviridova influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT enkologrivova influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT lveliseeva influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT ionaslednikova influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT oiurazova influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT vvnovitsky influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT ovvoronkova influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT nasukhalentseva influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis AT ebgorbunova influenceofherpessimplexviruspersistenceuponproductionofcytokinesbyimmunocompetentcellsinrheumatoidarthritis |