Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs
Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/1/110 |
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| author | Xiaoyuan Wei Kristopher A. Bottoms Hans H. Stein Laia Blavi Casey L. Bradley Jon Bergstrom Joshua Knapp Robert Story Charles Maxwell Tsungcheng Tsai Jiangchao Zhao |
| author_facet | Xiaoyuan Wei Kristopher A. Bottoms Hans H. Stein Laia Blavi Casey L. Bradley Jon Bergstrom Joshua Knapp Robert Story Charles Maxwell Tsungcheng Tsai Jiangchao Zhao |
| author_sort | Xiaoyuan Wei |
| collection | DOAJ |
| description | Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative control diet was included and the gut microbiota analysis was carried out. At both universities, increasing levels of sodium butyrate in a diet containing 0.5% benzoic acid improved growth performance, which reached a plateau in the pigs fed 0.035% (SBA0.035) or 0.070% (SBA0.070) butyrate. Gut microbiota analysis revealed that pigs fed the SBA0.035 diet had more diverse microbiota and contained more potentially beneficial bacteria such as <i>Oscillospira</i>, <i>Blautia</i>, and <i>Turicibacter</i> and reduced levels of <i>Veillonella</i> and <i>Sarcina</i>. Results of the present study indicated that the inclusion of sodium butyrate at moderate levels in a diet containing 0.5% benzoic acid improved growth performance of weaning pigs and established potential health benefits on gut microbiota. |
| first_indexed | 2024-03-10T13:29:05Z |
| format | Article |
| id | doaj.art-743f3a2e732e44328ca6b2ef35d5cbb9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T13:29:05Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-743f3a2e732e44328ca6b2ef35d5cbb92023-11-21T08:24:56ZengMDPI AGMicroorganisms2076-26072021-01-019111010.3390/microorganisms9010110Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery PigsXiaoyuan Wei0Kristopher A. Bottoms1Hans H. Stein2Laia Blavi3Casey L. Bradley4Jon Bergstrom5Joshua Knapp6Robert Story7Charles Maxwell8Tsungcheng Tsai9Jiangchao Zhao10Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USADepartment of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USADepartment of Animal Science, University of Illinois Urbana-Champaign, Champaign, IL 61801, USADepartment of Animal Science, University of Illinois Urbana-Champaign, Champaign, IL 61801, USAThe Sunswine Group, LLC, Lowell, AR 72745, USAAnimal Nutrition and Health, DSM Nutritional Products, Parsippany, NJ 07054, USADepartment of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USADepartment of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USADepartment of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USADepartment of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USADepartment of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USAFeed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative control diet was included and the gut microbiota analysis was carried out. At both universities, increasing levels of sodium butyrate in a diet containing 0.5% benzoic acid improved growth performance, which reached a plateau in the pigs fed 0.035% (SBA0.035) or 0.070% (SBA0.070) butyrate. Gut microbiota analysis revealed that pigs fed the SBA0.035 diet had more diverse microbiota and contained more potentially beneficial bacteria such as <i>Oscillospira</i>, <i>Blautia</i>, and <i>Turicibacter</i> and reduced levels of <i>Veillonella</i> and <i>Sarcina</i>. Results of the present study indicated that the inclusion of sodium butyrate at moderate levels in a diet containing 0.5% benzoic acid improved growth performance of weaning pigs and established potential health benefits on gut microbiota.https://www.mdpi.com/2076-2607/9/1/110benzoic acidgut microbiotagrowth performanceweaning pigssodium butyrate |
| spellingShingle | Xiaoyuan Wei Kristopher A. Bottoms Hans H. Stein Laia Blavi Casey L. Bradley Jon Bergstrom Joshua Knapp Robert Story Charles Maxwell Tsungcheng Tsai Jiangchao Zhao Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs Microorganisms benzoic acid gut microbiota growth performance weaning pigs sodium butyrate |
| title | Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs |
| title_full | Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs |
| title_fullStr | Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs |
| title_full_unstemmed | Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs |
| title_short | Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs |
| title_sort | dietary organic acids modulate gut microbiota and improve growth performance of nursery pigs |
| topic | benzoic acid gut microbiota growth performance weaning pigs sodium butyrate |
| url | https://www.mdpi.com/2076-2607/9/1/110 |
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